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The usefulness of the status of extranodal tumor extension as a factor that can predict the recurrence of stage III colorectal cancer

Title
The usefulness of the status of extranodal tumor extension as a factor that can predict the recurrence of stage III colorectal cancer
Author
백승삼
Keywords
Extranodal tumor extension; colorectal cancer; recurrence; vascular invasion; perforation
Issue Date
2019-01
Publisher
Taylor and Francis Ltd.
Citation
ACTA CHIRURGICA BELGICA, Page. 1-6
Abstract
Background: Extranodal tumor extension (ENTE) is considered a poor prognostic factor in colorectal cancer (CRC). This study aimed to investigate the risk factors for recurrence according to ENTE status in stage III CRC. Methods: We retrospectively evaluated 169 consecutive stage III CRC patients. All patients underwent a curative resection between 2005 and 2010. The presence or absence of ENTE was assessed in the resected lymph nodes. Results: ENTE was observed in 65 (38.5%). Recurrence occurred in 38 patients (22.5%) and was more frequent (p =.041) in the ENTE (+) group. Disease-free survival (p =.016) was significantly shorter in the ENTE (+) group than in the ENTE (−) group. In a univariable analysis, recurrence was associated with vascular invasion (p =.006), perforation (p =.024) in the ENTE (−) group and perforation (p =.048) in the ENTE (+) group. In a Cox’s regression test, vascular invasion (p =.014) and the higher ratio of metastatic lymph nodes/total removed lymph nodes (MLN/TLN) (0.009) in the ENTE (−) group and perforation (p =.025) in the ENTE (+) group were independent risk factors of recurrence. Conclusions: Vascular invasion and the higher ratio of MLN/TLN in ENTE (−) patients and perforation in ENTE (+) patients were independent risk factors of recurrence. © 2018, © 2019 The Royal Belgian Society for Surgery.
URI
https://www.tandfonline.com/doi/full/10.1080/00015458.2018.1549393http://repository.hanyang.ac.kr/handle/20.500.11754/111213
ISSN
0001-5458
DOI
10.1080/00015458.2018.1549393
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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