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dc.contributor.author민경환-
dc.date.accessioned2019-09-17T02:04:10Z-
dc.date.available2019-09-17T02:04:10Z-
dc.date.issued2019-03-
dc.identifier.citationPATHOLOGY RESEARCH AND PRACTICE, v. 215, NO 3, Page. 459-465en_US
dc.identifier.issn0344-0338-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0344033818312305?via%3Dihub-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/110453-
dc.description.abstractALK-positive (ALK+) lung adenocarcinoma usually shows a more advanced-staged disease with frequent nodal metastasis and highly aggressive outcomes compared with EGFR-mutated lung cancers. The aim of this study was to investigate the expression profiles of several mucins in ALK + lung cancers to gain insight into the relationship between the more aggressive biological nature of ALK + lung cancers and the role of mucins. We examined the immunohistochemical profiles of mucins MUC1, MUC2, MUC5AC, and MUC6 in 19 ALK + lung cancers compared with 42 EGFR-mutated lung cancers. ALK + cancers were found to occur in younger patients and were characterized by a solid-predominant histologic subtype with frequent signet ring cells and peritumoral muciphages. By contrast, EGFR-mutated cancers lacked ALK-specific histological patterns. Although all MUC1 and MUC5AC were expressed in both subtypes, MUC1 expression in ALK + cancers was visualized exclusively through cytoplasmic staining, whereas those in EGFR-mutated cancers were predominantly membranous staining in apical area (92.9%) and focally in cytoplasmic staining (7.1%). MUC5AC expression in ALK + cancers was exclusively visualized through cytoplasmic staining (100%), whereas EGFR-mutated cancers showed predominantly perinuclear dot-like patterns (90.5%) and focal cytoplasmic staining (9.5%). MUC2 and MUC6 expression was not detected in either type of lung cancer. CONCLUSIONS: The high frequency of both MUC1 and MUC5AC cytoplasmic expression, coupled with a lack of MUC2 and MUC6 expression in ALK + lung cancer may contribute to the biologically aggressive behavior of ALK + cancer. Inhibitors to these types of mucins may thus act as a barrier to cancerous extension reducing their aggressive behavior.en_US
dc.description.sponsorshipThis research was supported by the Hallym University Research Fund (HURF-2018-38) and Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education (NRF-2016R1D1A1B03935447).en_US
dc.language.isoenen_US
dc.publisherELSEVIER GMBHen_US
dc.subjectAnaplastic lymphoma kinaseen_US
dc.subjectMucinen_US
dc.subjectLung canceren_US
dc.subjectPrognosisen_US
dc.subjectImmunohistochemistryen_US
dc.titleExpression of mucins (MUC1, MUC2, MUC5AC and MUC6) in ALK-positive lung cancer: Comparison with EGFR-mutated lung canceren_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume215-
dc.identifier.doi10.1016/j.prp.2018.12.011-
dc.relation.page459-465-
dc.relation.journalPATHOLOGY RESEARCH AND PRACTICE-
dc.contributor.googleauthorLee, Hong Kyu-
dc.contributor.googleauthorKwon, Mi Jung-
dc.contributor.googleauthorSeo, Jinwon-
dc.contributor.googleauthorKim, Jeong Won-
dc.contributor.googleauthorHong, Mineui-
dc.contributor.googleauthorPark, Hye-Rim-
dc.contributor.googleauthorMin, Soo Kee-
dc.contributor.googleauthorChoe, Ji-Young-
dc.contributor.googleauthorRa, Yong Joon-
dc.contributor.googleauthorMin, Kyueng-Whan-
dc.relation.code2019000987-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidkyueng-
dc.identifier.researcherIDF-3981-2017-
dc.identifier.orcidhttps://orcid.org/0000-0002-4757-9211-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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