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폴록사머 및 프로필렌글리콜을 이용한 클로트리마졸 고형 좌제의 물리화학적 특성

Title
폴록사머 및 프로필렌글리콜을 이용한 클로트리마졸 고형 좌제의 물리화학적 특성
Other Titles
Physicochemical Characterization of Clotrimazole-Loaded Solid Suppository Using Poloxamer and Propylene Glycol
Author
최한곤
Keywords
clotrimazole; propylene glycol; poloxamer 188; suppository; melting point
Issue Date
2005-04
Publisher
한국약제학회
Citation
한국약제학회지, v. 35, No. 2, Page. 107-110
Abstract
To develop a clotrimazole-loaded solid suppository with poloxamer and propylene glycol, the melting points of various formulations composed of poloxamer 188 (P 188) and propylene glycol were investigated. The dissolution study of clotrimazole delivered by the suppository composed of P 188 and propylene glycol was performed. The mixtures composed of P 188 and propylene glycol were homogeneous. Propylene glycol affected the melting points of poloxamer mixtures. In particular, the mixture [P 188/propylene glycol (70/30%)] with the melting point of about 32°C was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, propylene glycol affected greatly the dissolution rates of clotrimazole from the suppository. Dissolution mechanism analysis showed the dissolution of clotrimazole was proportional to the time. Our results indicated that the solid suppository with P 188 and propylene glycol would be a candidate of rectal dosage form for clotrimazole.
URI
http://kiss.kstudy.com/thesis/thesis-view.asp?key=2436030http://repository.hanyang.ac.kr/handle/20.500.11754/110386
ISSN
2093-5552
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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