8 0

HPLC method for the pharmacokinetics study of acemetacin in human plasma

Title
HPLC method for the pharmacokinetics study of acemetacin in human plasma
Author
김진기
Keywords
acemetacin; indometacin; high performance liquid chromatography (HPLC)
Issue Date
2005-02
Publisher
TAYLOR & FRANCIS INC
Citation
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, v. 28, No. 10, Page. 1593-1604
Abstract
A reproducible and specific high performance liquid chromatography (HPLC) method was developed to quantity plasma levels of acemetacin and its metabolite, indometacin in order to conduct a pharmacokinetics study. Plasma samples were prepared by liquid-liquid extraction using ethyl acetate.- Extracted samples were analyzed on a reverse-phase C-18 column with a mobile phase consisting of 20mM phosphate buffer (pH 2.9) and acetonitrile (60:40, v/v) and UV detection at 254nm. Using this method, the phannacokinctics study was carried out on eight volunteers after a single oral administration.
URI
https://www.tandfonline.com/doi/full/10.1081/JLC-200058377http://repository.hanyang.ac.kr/handle/20.500.11754/110200
ISSN
1082-6076
DOI
10.1081/JLC-200058377
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE