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dc.contributor.author이수진-
dc.date.accessioned2019-09-03T00:36:05Z-
dc.date.available2019-09-03T00:36:05Z-
dc.date.issued2019-03-
dc.identifier.citationJOURNAL OF CLINICAL MEDICINE, v. 8, NO 3, no. 296en_US
dc.identifier.issn2077-0383-
dc.identifier.urihttps://www.mdpi.com/2077-0383/8/3/296-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/110089-
dc.description.abstractThe impact of menopausal transition on change of serum uric acid level remains unknown. The present study evaluated the relationship of menopausal stages with prevalent hyperuricemia in middle-aged women. This cross-sectional study included 58,870 middle-aged Korean women, aged >= 40, who participated in a health examination from 2014 to 2016. Menopausal stages were obtained with a standardized, self-administered questionnaire and were categorized according to the criteria of the Stages of Reproductive Aging Workshop (STRAW+10). Hyperuricemia was defined as a serum uric acid level of >= 6 mg/dL. The prevalence of hyperuricemia increased as menopausal stage increased. The multivariable-adjusted odds ratios (95% confidence intervals) for prevalent hyperuricemia comparing early transition, late transition, and post-menopause to pre-menopause were 1.19 (0.80-1.77), 2.13 (1.35-3.36), and 1.65 (1.33-2.04), respectively. This association was stronger among non-obese compared to obese participants and in those with low high-sensitivity C-reactive protein (hsCRP) levels (<1.0 mg/L) compared to those with elevated hsCRP levels of >= 1.0 mg/L (p for interaction = 0.01). In this large sample of middle-aged women, the prevalence of hyperuricemia significantly increased from the menopausal stage of late transition, independent of potential confounders. Appropriate preventive strategies for reducing hyperuricemia and its related consequences should be initiated prior to menopause.en_US
dc.description.sponsorshipThis research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1A6A3A11933380) and by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (Grant Number: HI17C2372). This research was also supported in part by the Intramural Research Program of the NIH, National Cancer Institute, and Center for Cancer Research. This project has been funded in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN26120080001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does the mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjecthyperuricemiaen_US
dc.subjectmenopauseen_US
dc.subjectlate menopausal stageen_US
dc.titleThe Prevalence of Hyperuricemia Sharply Increases from the Late Menopausal Transition Stage in Middle-Aged Womenen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume8-
dc.identifier.doi10.3390/jcm8030296-
dc.relation.page1-10-
dc.relation.journalJOURNAL OF CLINICAL MEDICINE-
dc.contributor.googleauthorCho, Sung Kweon-
dc.contributor.googleauthorWinkler, Cheryl A.-
dc.contributor.googleauthorLee, Soo-Jin-
dc.contributor.googleauthorChang, Yoosoo-
dc.contributor.googleauthorRyu, Seungho-
dc.relation.code2019044887-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidsjlee-
dc.identifier.orcidhttps://orcid.org/0000-0002-4938-1700-


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