Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 성일훈 | - |
dc.date.accessioned | 2019-08-29T02:32:37Z | - |
dc.date.available | 2019-08-29T02:32:37Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.citation | BMB REPORTS, v. 52, no. 6, Page. 391-396 | en_US |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | http://www.bmbreports.org/journal/view.html?uid=1384&vmd=Full | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/110050 | - |
dc.description.abstract | Receptor activator of nuclear factor kappa B ligand (RANKL) expression in osteoblasts is regulated by 1,25-dihydroxyvitamin D3 (1,25D3). CCAAT/enhancer-binding protein beta (C/EBP beta) has been proposed to function as a transcription factor and upregulate RANKL expression, but it is still uncertain how C/EBP beta is involved in 1,25D3-induced RANKL expression of osteoblasts. 1,25D3 stimulation increased the expression of RANKL and C/EPB beta genes in osteoblasts and enhanced phosphorylation and stability of these proteins. Moreover, induction of RANKL expression by 1,25D3 in osteoblasts was downregulated upon knockdown of C/EBP beta. In contrast, C/EBP beta overexpression directly upregulated RANKL promoter activity and exhibited a synergistic effect on 1,25D3-induced RANKL expression. In particular, 1,25D3 treatment of osteoblasts increased C/EBP beta protein binding to the RANKL promoter. In conclusion, C/EBP beta is required for induction of RANKL by 1,25D3. | en_US |
dc.description.sponsorship | This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, & Future (NRF-2016R1A2B4008606) and the Ministry of Education (2017R1A6A3A11034394). The study was also supported by a Korea Health Technology R&D grant through the Korea Health Industry Development Institute (KHIDI), which is funded by the Ministry of Health & Welfare, Republic of Korea (HI17C0888). | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | en_US |
dc.subject | 1,25-dihydroxyvitamin D3 (1,25D3) | en_US |
dc.subject | C/EBP beta | en_US |
dc.subject | Osteoblasts | en_US |
dc.subject | RANKL | en_US |
dc.title | CCAAT/enhancer-binding protein beta (C/EBPβ) is an important mediator of 1,25 dihydroxyvitamin D3 (1,25D3)-induced receptor activator of nuclear factor kappa-B ligand (RANKL) expression in osteoblasts. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.5483/BMBRep.2019.52.6.166 | - |
dc.relation.page | 1-35 | - |
dc.relation.journal | BMB REPORTS | - |
dc.contributor.googleauthor | Jo, Sungsin | - |
dc.contributor.googleauthor | Lee, Yun Young | - |
dc.contributor.googleauthor | Han, Jinil | - |
dc.contributor.googleauthor | Lee, Young Lim | - |
dc.contributor.googleauthor | Yoon, Subin | - |
dc.contributor.googleauthor | Lee, Jaehyun | - |
dc.contributor.googleauthor | Oh, Younseo | - |
dc.contributor.googleauthor | Han, Joong-Soo | - |
dc.contributor.googleauthor | Sung, Il-Hoon | - |
dc.contributor.googleauthor | Park, Ye-Soo | - |
dc.relation.code | 2019037758 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | sungih | - |
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