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CCAAT/enhancer-binding protein beta (C/EBPβ) is an important mediator of 1,25 dihydroxyvitamin D3 (1,25D3)-induced receptor activator of nuclear factor kappa-B ligand (RANKL) expression in osteoblasts.

Title
CCAAT/enhancer-binding protein beta (C/EBPβ) is an important mediator of 1,25 dihydroxyvitamin D3 (1,25D3)-induced receptor activator of nuclear factor kappa-B ligand (RANKL) expression in osteoblasts.
Author
성일훈
Keywords
1,25-dihydroxyvitamin D3 (1,25D3); C/EBP beta; Osteoblasts; RANKL
Issue Date
2019-02
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Citation
BMB REPORTS, v. 52, no. 6, Page. 391-396
Abstract
Receptor activator of nuclear factor kappa B ligand (RANKL) expression in osteoblasts is regulated by 1,25-dihydroxyvitamin D3 (1,25D3). CCAAT/enhancer-binding protein beta (C/EBP beta) has been proposed to function as a transcription factor and upregulate RANKL expression, but it is still uncertain how C/EBP beta is involved in 1,25D3-induced RANKL expression of osteoblasts. 1,25D3 stimulation increased the expression of RANKL and C/EPB beta genes in osteoblasts and enhanced phosphorylation and stability of these proteins. Moreover, induction of RANKL expression by 1,25D3 in osteoblasts was downregulated upon knockdown of C/EBP beta. In contrast, C/EBP beta overexpression directly upregulated RANKL promoter activity and exhibited a synergistic effect on 1,25D3-induced RANKL expression. In particular, 1,25D3 treatment of osteoblasts increased C/EBP beta protein binding to the RANKL promoter. In conclusion, C/EBP beta is required for induction of RANKL by 1,25D3.
URI
http://www.bmbreports.org/journal/view.html?uid=1384&vmd=Fullhttp://repository.hanyang.ac.kr/handle/20.500.11754/110050
ISSN
1976-6696; 1976-670X
DOI
10.5483/BMBRep.2019.52.6.166
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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