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dc.contributor.author배옥남-
dc.date.accessioned2019-08-27T08:05:45Z-
dc.date.available2019-08-27T08:05:45Z-
dc.date.issued2006-12-
dc.identifier.citationJournal of Toxicology and Public Health, v. 22, No. 4, Page. 397-402en_US
dc.identifier.issn1976-8257-
dc.identifier.urihttp://www.dbpia.co.kr/journal/articleDetail?nodeId=NODE00802198&language=ko_KR-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/110032-
dc.description.abstractLipid mediator such as lysophosphatidic acid (LPA) plays an important role in inflammation and wound healing, has been recently reported to induce influx of extracellular calcium into erythrocytes. This elevation in intracellular calcium level may cause destruction of membrane asymmetry and procoagulant microvesicle formation. Thus, we investigated if the lipid mediator could induce microvesicle formation as a result of extracellular calcium influx in human erythrocytes. Treatment with lipid mediator to erythrocytes resulted in microvesicle generation in a concentration-, timedependent manner. Microvesicles formed expressed procoagulant phosphatidylserine (PS) on their surface membrane significantly as well. LPA did not affect the band 3 phosphorylation which is involved in morphological change in erythrocytes. Pretreatment with suramin did not inhibit LPAinduced microvesicle generation, suggesting microvesicle generation was not receptor-dependent pathway. Depletion of intracellular ATP levels in erythrocytes was suggested to be one of the mechanism for these events.en_US
dc.language.isoko_KRen_US
dc.publisher한국독성학회en_US
dc.subjectErythrocyesen_US
dc.subjectLysophosphatidic aciden_US
dc.subjectPhosphatidylserineen_US
dc.subjectMicrovesicleen_US
dc.titleLipid Mediator에 의한 적혈구 Microvesicle 생성에 대한 연구en_US
dc.title.alternativeMicrovesicle Generation by Lipid Mediator in Erythrocytesen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume22-
dc.relation.page397-402-
dc.relation.journal한국독성학회지(Journal of Toxicology and Public Health)-
dc.contributor.googleauthor정승민-
dc.contributor.googleauthor배옥남-
dc.contributor.googleauthor노지윤-
dc.contributor.googleauthor김수진-
dc.contributor.googleauthor임경민-
dc.contributor.googleauthor정진호-
dc.relation.code2012214497-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidonbae-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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