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Lipid Mediator에 의한 적혈구 Microvesicle 생성에 대한 연구

Title
Lipid Mediator에 의한 적혈구 Microvesicle 생성에 대한 연구
Other Titles
Microvesicle Generation by Lipid Mediator in Erythrocytes
Author
배옥남
Keywords
Erythrocyes; Lysophosphatidic acid; Phosphatidylserine; Microvesicle
Issue Date
2006-12
Publisher
한국독성학회
Citation
Journal of Toxicology and Public Health, v. 22, No. 4, Page. 397-402
Abstract
Lipid mediator such as lysophosphatidic acid (LPA) plays an important role in inflammation and wound healing, has been recently reported to induce influx of extracellular calcium into erythrocytes. This elevation in intracellular calcium level may cause destruction of membrane asymmetry and procoagulant microvesicle formation. Thus, we investigated if the lipid mediator could induce microvesicle formation as a result of extracellular calcium influx in human erythrocytes. Treatment with lipid mediator to erythrocytes resulted in microvesicle generation in a concentration-, timedependent manner. Microvesicles formed expressed procoagulant phosphatidylserine (PS) on their surface membrane significantly as well. LPA did not affect the band 3 phosphorylation which is involved in morphological change in erythrocytes. Pretreatment with suramin did not inhibit LPAinduced microvesicle generation, suggesting microvesicle generation was not receptor-dependent pathway. Depletion of intracellular ATP levels in erythrocytes was suggested to be one of the mechanism for these events.
URI
http://www.dbpia.co.kr/journal/articleDetail?nodeId=NODE00802198&language=ko_KRhttp://repository.hanyang.ac.kr/handle/20.500.11754/110032
ISSN
1976-8257
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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