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An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius

Title
An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius
Author
유혜현
Keywords
Carthamus tinctorius; tracheloside; anti-estrogenic activity; Ishikawa cell; bioassay-linked HPLC-ELSD
Issue Date
2006-11
Publisher
JAPAN SOC BIOSCI BIOTECHN AGROCHEM
Citation
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v. 70, No. 11, Page. 2783-2785
Abstract
The lignan glycoside, tracheloside, was isolated from seeds of Carthamus tinctorius (Compositae) as an anti-estrogenic principle against cultured Ishikawa cells by employing a bioassay-linked HPLC-ELSD method. Tracheloside significantly decreased the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC50 value of 0.31 mu g/ml, a level of inhibition comparable to that of tamoxifen (IC50 = 0.43 mu g/ml).
URI
https://www.jstage.jst.go.jp/article/bbb/70/11/70_60290/_article/-char/ja/http://repository.hanyang.ac.kr/handle/20.500.11754/108817
ISSN
0916-8451; 1347-6947
DOI
10.1271/bbb.60290
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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