Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2019-08-16T04:46:10Z | - |
dc.date.available | 2019-08-16T04:46:10Z | - |
dc.date.issued | 2006-10 | - |
dc.identifier.citation | 약제학회지, v. 36, No. 5, Page. 321-329 | en_US |
dc.identifier.issn | 2093-5552 | - |
dc.identifier.uri | http://kiss.kstudy.com/thesis/thesis-view.asp?key=2575160 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/108689 | - |
dc.description.abstract | Albuterol, a selective 2-adrenergic receptor stimulant, has been introduced as a potent bronchodilator for patients with bronchial asthma, chronic obstructive bronchial disease, chronic bronchitis and pulmonary emphysema. The percutaneous permeation of albuterol sulfate was investigated in hairless mouse skin in vitro with and without pretreatment with enhancers. The enhancing effects of ethanol and various penetration enhancers such as terpenes, non-ionic surfactants, pyrrolidones, and fatty acids on the permeation of albuterol sulfate were evaluated using Franz diffusion cells. Among terpenes studied, 1,8-cineole was the most effective enhancer, which increased the permeability of albuterol sulfate approximately 33-fold compared with the control without enhancer pretrement, followed by d-limonene with enhancement ratio of 21.79. 2-Pyrrolidone-5-carboxylic acid increased the permeability of albuterol sulfate approximately 5.5-fold compared with the control. Other pyrrolidones tested showed only slight permeability enhancing effect with enhancement ratio less than 2.8. Nonionic surfactants showed moderate enhancing effects. Lauric acid increased the permeability of albuterol sulfate approximately 30-fold with decreasing the lag time from 2.85 to 0.64 hr. Oleic acid and linoleic acid showed enhancement ratio of 24.55 and 22.91, respectively. These findings would allow a more rational approach for designing formulations for the transdermal delivery of albuterol sulfate and similar drugs. | en_US |
dc.language.iso | ko_KR | en_US |
dc.publisher | 한국약제학회 | en_US |
dc.subject | Albuterol | en_US |
dc.subject | Enhancer | en_US |
dc.subject | Transdermal drug delivery systems | en_US |
dc.subject | Permeability | en_US |
dc.title | The Effect of Enhancers on the Penetration of Albuterol through Hairless Mouse Skin | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 36 | - |
dc.relation.page | 321-329 | - |
dc.relation.journal | 약제학회지 | - |
dc.contributor.googleauthor | Choi, Han Gon | - |
dc.contributor.googleauthor | Rhee, Jong Dal | - |
dc.contributor.googleauthor | Yu, Bong Kyu | - |
dc.contributor.googleauthor | Kim, Jung Ae | - |
dc.contributor.googleauthor | Kwak, Mi Kyung | - |
dc.contributor.googleauthor | Woo, Jong Soo | - |
dc.contributor.googleauthor | Oh, Dong Hun | - |
dc.contributor.googleauthor | Han, Myo Jung | - |
dc.contributor.googleauthor | Choi, Jun Young | - |
dc.contributor.googleauthor | Piao, Ming Guan | - |
dc.contributor.googleauthor | Yong, Chul Soon | - |
dc.relation.code | 2012215153 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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