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Estrogenic activity of furanocoumarins isolated from Angelica dahurica

Title
Estrogenic activity of furanocoumarins isolated from Angelica dahurica
Author
유혜현
Keywords
Angelica dahurica; Umbelliferae; furanocoumarin; estrogenic activity
Issue Date
2006-09
Publisher
PHARMACEUTICAL SOCIETY KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v. 29, No. 9, Page. 741-745
Abstract
In our efforts to discover novel phytoestrogens to treat menopausal symptoms, eleven furanocoumarins were isolated from Angelica dahurica and tested for their estrogenic activity on the Ishikawa cell line. Among the compounds tested, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin showed strong abilities to induce alkaline phosphatase (AP) with EC50 values of 1.1 and 0.8 mu g/mL, respectively, whereas the other nine furanocoumarins were weakly or only slightly active.
URI
https://link.springer.com/article/10.1007/BF02974073http://repository.hanyang.ac.kr/handle/20.500.11754/108514
ISSN
0253-6269; 1976-3786
DOI
10.1007/BF02974073
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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