Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2019-08-13T01:47:46Z | - |
dc.date.available | 2019-08-13T01:47:46Z | - |
dc.date.issued | 2006-09 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 321, No. 1-2, Page. 56-61 | en_US |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.issn | 1873-3476 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0378517306003681 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/108507 | - |
dc.description.abstract | To develop a novel clotrimazole-loaded poloxamer-based suppository with enhanced anti-tumor activity and alleviated hepatotoxicity, the melting point of various formulations composed of P 188 and propylene glycol were investigated. The dissolution and anti-tumor activity of clotrimazole delivered by the poloxamer-based suppository was performed. Furthermore, the hepatotoxicity of clotrimazole was carried out after its rectal administration compared to oral administration in mice. The poloxamer mixtures composed of P 188 and propylene glycol were homogeneous phases. P 188 greatly affected the melting point of poloxamer mixtures. In particular, the poloxamer mixture [P 188/propylene glycol (70%/30%)] with the melting point of about 32 degrees C was a solid form at room temperature and instantly melted at physiological temperature. The ratio of P 188/propylene glycol greatly affected the dissolution rates of clotrimazole from poloxamer-based suppository. Dissolution mechanism analysis showed the dissolution rate of clotrimazole from poloxamer-based suppositories was independent of the time. The clotrimazole-loaded suppository with P 188 and propylene glycol could not irritate or damage the rectal tissues of rats and gave the improved anti-tumor activity in a dose-dependent manner at mouse. Furthermore, its rectal administration decreased the hepatotoxicity compared to oral administration. Thus, the poloxamer-based solid suppository system with clotrimazole/P 188/propylene glycol was an effective rectal dosage form for the treatment of tumors with alleviated adverse effects. (c) 2006 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This research was supported by the Regional R&D Cluster Project designated by the Ministry of Science and Technology & the Ministry of Commerce, Industry, and Energy (2005) and supported by a program for cultivating graduate students in regional strategic industry from the Korea Industrial Technology Foundation (KITF 00-B-106-108). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | clotrimazole | en_US |
dc.subject | poloxamer 188 | en_US |
dc.subject | suppository | en_US |
dc.subject | melting point | en_US |
dc.subject | anti-tumor activity | en_US |
dc.subject | hepatotoxicity | en_US |
dc.title | Enhanced anti-tumor activity and alleviated hepatotoxicity of clotrimazole-loaded suppository using poloxamer-propylene glycol gel | en_US |
dc.type | Article | en_US |
dc.relation.volume | 321 | - |
dc.identifier.doi | 10.1016/j.ijpharm.2006.05.023 | - |
dc.relation.page | 56-61 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.contributor.googleauthor | Yong, Chul Soon | - |
dc.contributor.googleauthor | Xuan, Jing Ji | - |
dc.contributor.googleauthor | Paek, Seung-Hwan | - |
dc.contributor.googleauthor | Oh, Yu-Kyoung | - |
dc.contributor.googleauthor | Woo, Jong-Soo | - |
dc.contributor.googleauthor | Lee, Mann Hyung | - |
dc.contributor.googleauthor | Kim, Jung-Ae | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.relation.code | 2009204294 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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