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dc.contributor.author계명찬-
dc.date.accessioned2019-08-07T02:30:07Z-
dc.date.available2019-08-07T02:30:07Z-
dc.date.issued2019-02-
dc.identifier.citationENVIRONMENTAL RESEARCH, v. 172, Page. 10-17en_US
dc.identifier.issn0013-9351-
dc.identifier.issn1096-0953-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S001393511930074X?via%3Dihub-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/108288-
dc.description.abstractPlastic products are closely intertwined with modern life. Some plasticizers used in making plastics, such as phthalates, are reported to be endocrine-disrupting chemicals. Plasticizers can be released into the environment, and health risks related to plasticizer exposure have been reported. In addition, due to plastic waste that flows into the ocean, microplastics have been found in marine products, including non-biological seawater products such as sea salt. Plastics can affect the body via a variety of pathways, and therefore safer alternative chemicals are needed. Three chemicals were evaluated: acetyl tributyl citrate (ATBC), triethyl 2-acetylcitrate (ATEC), and trihexyl O-acetylacitrate (ATHC), replacing bis(2-ethylhexyl)phthalate (DEHP), a typical plasticizer. The endocrine -disrupting activities of each chemical, including estrogenic or anti-estrogenic activity (test guideline (TG) No. 455), androgenic or anti-androgenic activity (TG No. 458), steroidogenesis (TG No. 456), and estrogenic properties via a short-term screening test using the uterotrophic assay (TG No. 440), were assessed in accordance with the Organisation for Economic Co-operation and Development guidelines for chemical testing. Our results showed that DEHP, ATBC, ATEC, ATHC possess no estrogenic activity, whereas DEHP, ATBC and ATHC demonstrate anti-estrogenic activity and ATBC anti-androgenic activity. DEHP and ATHC exhibited a disruption in steroidogenesis activities. Additional tests are necessary, but our results suggest that ATEC is a good candidate plasticizer providing a suitable alternative to DEHP.en_US
dc.description.sponsorshipThis research was supported by Research Program to Solve Social Issues of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT. (No. NRF-2017M3C8A6091777).en_US
dc.language.isoenen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.subjectEndocrine disruptoren_US
dc.subjectPhthalateen_US
dc.subjectAlternative materialen_US
dc.titleAssessment of endocrine-disrupting activities of alternative chemicals for bis(2-ethylhexyl)phthalateen_US
dc.typeArticleen_US
dc.relation.volume172-
dc.identifier.doi10.1016/j.envres.2019.02.001-
dc.relation.page10-17-
dc.relation.journalENVIRONMENTAL RESEARCH-
dc.contributor.googleauthorPark, Joonwoo-
dc.contributor.googleauthorPark, Choa-
dc.contributor.googleauthorGye, Myung Chan-
dc.contributor.googleauthorLee, Youngjoo-
dc.relation.code2019000322-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidmcgye-
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COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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