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Establishing a human adrenocortical carcinoma (ACC)-specific gene mutation signature

Title
Establishing a human adrenocortical carcinoma (ACC)-specific gene mutation signature
Author
Heese, Klaus
Keywords
Adrenal gland; CRIPAK; DGKZ; LRIG1; Oncogene; ZFPM1; Zinc finger
Issue Date
2019-01
Publisher
ELSEVIER SCIENCE INC
Citation
CANCER GENETICS, v. 230, Page. 1-12
Abstract
Adrenocortical carcinoma (ACC) is a rare and aggressive tumor whose molecular signaling pathways are not fully understood. Using an in-silico clinical data analysis approach we retrieved human gene mutation data from the highly reputed Cancer Genome Atlas (TCGA). ACC-specific gene mutations were correlated with proliferation marker FAM72 expression and Mutsig along with the algorithmic implementation of the 20/20 rule were used to validate their oncogenic potential. The newly identified oncogenic driver gene set (ZFPM1, LRIG1, CRIPAK, ZNF517, GARS and DGKZ), specifically and most repeatedly mutated in ACC, is involved in tumor suppression and cellular proliferation and thus could be useful for the prognosis and development of therapeutic approaches for the treatment of ACC.
URI
https://www.sciencedirect.com/science/article/pii/S2210776218303661?via%3Dihubhttp://repository.hanyang.ac.kr/handle/20.500.11754/108074
ISSN
2210-7762; 2210-7770
DOI
10.1016/j.cancergen.2018.10.005
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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