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Proteogenomic Characterization of Human Early-Onset Gastric Cancer

Title
Proteogenomic Characterization of Human Early-Onset Gastric Cancer
Author
박희진
Keywords
MICROSATELLITE INSTABILITY; MOLECULAR SUBTYPES; SIGNALING PATHWAY; DATABASE SEARCH; ACCURATE MASS; IDENTIFICATION; MUTATIONS; DISCOVERY; GENE; KINASE
Issue Date
2019-01
Publisher
CELL PRESS
Citation
CANCER CELL, v. 35, NO 1, Page. 111-124
Abstract
We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune-and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs.
URI
https://www.sciencedirect.com/science/article/pii/S1535610818305749?via%3Dihubhttp://repository.hanyang.ac.kr/handle/20.500.11754/107955
ISSN
1535-6108; 1878-3686
DOI
10.1016/j.ccell.2018.12.003
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > COMPUTER SCIENCE(컴퓨터소프트웨어학부) > Articles
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