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Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites

Title
Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites
Author
안성훈
Keywords
histone deacetylase; apicidin; cyclin E; Sp1; E2F
Issue Date
2006-04
Publisher
ACADEMIC PRESS INC
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v. 342, No. 4, Page. 1168-1173
Abstract
We show that a histone deacetylase (HDAC) inhibitor apicidin increases the transcriptional activity of cyclin E gene, which results in accumulation of cyclin E mRNA and protein in a time- and close-dependent manner. Interestingly, apicidin induction of cyclin E gene is found to be mediated by Sp1- rather than E21F-bincling sites in the cyclin E promoter, as evidenced by the fact that specific inhibition of Sp1 leads to a decrease in apicidin activation of cyclin E promoter activity and protein expression, but mutation of E2F-binding sites of cyclin E promoter region fails to inhibit the ability of apicidin to activate cyclin E transcription. In addition, this transcriptional activation of cyclin E by apicidin is associated with historic hyperacetylation of cyclin E promoter region containing Sp1-binding sites. Our results demonstrate that regulation of historic modification by an HDAC inhibitor apicidin contributes to induction of cyclin E expression and this effect is Sp1-dependent. (c) 2006 Elsevier Inc. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0006291X06003822http://repository.hanyang.ac.kr/handle/20.500.11754/107864
ISSN
0006-291X; 1090-2104
DOI
10.1016/j.bbrc.2006.02.081
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MOLECULAR AND LIFE SCIENCE(분자생명과학과) > Articles
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