Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2019-07-12T01:09:06Z | - |
dc.date.available | 2019-07-12T01:09:06Z | - |
dc.date.issued | 2007-11 | - |
dc.identifier.citation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, v. 30, No. 11, Page. 2211-2216 | en_US |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://www.jstage.jst.go.jp/article/bpb/30/11/30_11_2211/_article/-char/ja/ | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/107328 | - |
dc.description.abstract | The purpose of this study was to evaluate the physicochemical properties, skin permeation and accumulation profiles of model lipophilic ketorolac fatty ester (esters) prodrugs. Ketorolac linoleate (C18:2), oleate (C18:1) and stearate (C18:0) were evaluated for their solubility, capacity factor, enzymatic hydrolysis, chemical stability, and skin permeation and accumulation profiles using the combination of common permeation enhancing techniques such as the use of supersaturated solution of permeants in the enhancer vehicle, lipophilic receptor solution, enhancer pretreatment of skins, removal of stratum corneum and delipidization of skins etc. Esters were highly lipophilic, chemically stable for the duration of observation, enzymatically unstable in hairless mouse skin/liver homogenates and plasma, and impermeable into the receptor solution. Absence of skin permeation, relative enzymatic stability during permeation and chemical stability of these esters could delineate preliminary possibilities for designing safer topical agents without systemic absorption. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PHARMACEUTICAL SOC JAPAN | en_US |
dc.subject | ketorolac fatty ester prodrug | en_US |
dc.subject | skin permeation | en_US |
dc.subject | skin accumulation | en_US |
dc.title | Evaluation of physicochemical properties, skin permeation and accumulation profiles of ketorolac fatty ester prodrugs | en_US |
dc.type | Article | en_US |
dc.relation.volume | 30 | - |
dc.identifier.doi | 10.1248/bpb.30.2211 | - |
dc.relation.page | 2211-2216 | - |
dc.relation.journal | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.contributor.googleauthor | Bhandari, Krishna Hari | - |
dc.contributor.googleauthor | Newa, Madhuri | - |
dc.contributor.googleauthor | Il Yoon, Sung | - |
dc.contributor.googleauthor | Kim, Jung Sun | - |
dc.contributor.googleauthor | Jang, Ki Young | - |
dc.contributor.googleauthor | Kim, Jung-Ae | - |
dc.contributor.googleauthor | Yoo, Bong Kyo | - |
dc.contributor.googleauthor | Woo, Jong Soo | - |
dc.contributor.googleauthor | Lee, Jae Hwi | - |
dc.contributor.googleauthor | Choi, Hang Gon | - |
dc.contributor.googleauthor | Kim, Dae Duk | - |
dc.contributor.googleauthor | Yong, Chul Soon | - |
dc.relation.code | 2007201283 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.