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dc.contributor.author박용천-
dc.date.accessioned2019-07-11T06:06:39Z-
dc.date.available2019-07-11T06:06:39Z-
dc.date.issued2019-02-
dc.identifier.citationSAUDI PHARMACEUTICAL JOURNAL, v. 27, NO 2, Page. 246-253en_US
dc.identifier.issn1319-0164-
dc.identifier.issn2213-7475-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1319016418305681?via%3Dihub-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/107316-
dc.description.abstractBackground: Although disorganized speech is seen as one of the nuclear features of schizophrenia, there have been few reports of disorganized speech-associated psychotropic drug-prescribing patterns in large samples of schizophrenia patients. Objective: We aimed to examine the prevalence of disorganized speech and its correlates in terms of psychotropic drug prescribing, using the data from the Research on Asian Psychotropic Patterns for Antipsychotics (REAP-AP) study. Method: A total of 3744 patients with the ICD-10 diagnosis of schizophrenia were enrolled from 71 survey centers in 15 Asian countries/areas. An essential criterion of disorganized speech was that it was "severe enough to impair substantially effective communication" as defined in the DSM-5. A binary logistic model was fitted to identify the psychotropic drug-prescribing correlates of disorganized speech. Results: After adjusting for the potential effects of confounding variables, the binary logistic regression model showed that the presence of disorganized speech was directly associated with adjunctive use of mood stabilizers (P ˂ 0.001) and cumulative diazepam equivalent dose (P ˂ 0.0001), and inversely associated with adjunctive use of anti-Parkinson drugs (P ˂ 0.0001). Conclusion: The association between disorganized speech and adjunctive use of mood stabilizers could perhaps be understood in the context of a relationship with impulsiveness/aggressiveness, or in terms of deconstructing the Kraepelinian dualism. (C) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.en_US
dc.description.sponsorshipThis research was supported by the grant from Taipei City Hospital (10501-62-012), Taipei, Taiwan. All members of the REAP-AP study are listed on the REAP homepage available from: http://reap.asia/.en_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectAsianen_US
dc.subjectDisorganized speechen_US
dc.subjectMood stabilizersen_US
dc.subjectSchizophreniaen_US
dc.titlePsychotropic drug-prescribing correlates of disorganized speech in Asians with schizophrenia: The REAP-AP studyen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume27-
dc.identifier.doi10.1016/j.jsps.2018.11.006-
dc.relation.page246-253-
dc.relation.journalSAUDI PHARMACEUTICAL JOURNAL-
dc.contributor.googleauthorPark, Yong Chon-
dc.contributor.googleauthorLee, Min-Soo-
dc.contributor.googleauthorSi, Tian-Mei-
dc.contributor.googleauthorChiu, Helen F.K.-
dc.contributor.googleauthorKariba, Shigenobu-
dc.contributor.googleauthorChong, Mian-Yoon-
dc.contributor.googleauthorTripathi, Adarsh-
dc.contributor.googleauthorUdomratn, Pichet-
dc.contributor.googleauthorChee, Kok Yoon-
dc.contributor.googleauthorTanra, Andi J.-
dc.relation.code2019042346-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidhypyc-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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