Preparation of ketoprofen-loaded high-molecular weight poly(vinyl alcohol) gels
- Title
- Preparation of ketoprofen-loaded high-molecular weight poly(vinyl alcohol) gels
- Author
- 최한곤
- Keywords
- high-molecular weight; a-PVA gel; ketoprofen
- Issue Date
- 2007-12
- Publisher
- JOHN WILEY & SONS INC
- Citation
- JOURNAL OF APPLIED POLYMER SCIENCE, v. 106, No. 5, Page. 3268-3272
- Abstract
- High-molecular-weight atactic poly(vinyl alcohol) (a-PVA) gels loaded with (R,S)-2-(3-benzoylphenyl)propionic acid (ketoprofen) were prepared from 5, 6, 7, and 8 g/dL solutions of a-PVA with a number-average degree of polymerization of 4000 in an ethylene glycol/ water mixture with an aging method to identify the effect of the initial polymer concentration on the swelling behavior, morphology, and thermal properties of a-PVA gels. Then, the release behavior of ketoprofen from a-PVA gels was investigated. As the polymer concentration decreased, the ability for network formation decreased, and the degree of swelling of the a-PVA gels increased. In addition, the enthalpy increased with an increase in the a-PVA concentration, but the melting temperatures of the gels prepared at different initial polymer concentrations were the same; this indicated that tighter gel networks would be formed by a higher polymer chain density. (c) 2007 Wiley Periodicals, Inc.
- URI
- https://onlinelibrary.wiley.com/doi/full/10.1002/app.25991https://repository.hanyang.ac.kr/handle/20.500.11754/107096
- ISSN
- 0021-8995
- DOI
- 10.1002/app.25991
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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