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Effect of Additive of the Encapsulated Amounts and Solubility of Poorly Water-soluble Ibuprofen in Gelatin Microcapsules

Title
Effect of Additive of the Encapsulated Amounts and Solubility of Poorly Water-soluble Ibuprofen in Gelatin Microcapsules
Author
최한곤
Keywords
Gelatin; Microcapsule; Solubility; Ibuprofen; Spray drying; Ethanoll. Introduction
Issue Date
2007-10
Publisher
한국약제학회
Citation
약제학회지, v. 37, No. 5, Page. 269-273
Abstract
Poorly water-soluble ibuprofen and ethanol can be encapsulated in gelatin microcapsule by spray drying technique. To select an optimal formula of ibuprofen-loaded gelatin microcapsule which increased the ethanol content and ibuprofen solubility with the decreased amount of gelatin in the microcapsules, in this study, the effect of gelatin, ibuprofen and sodium lauryl sulfate on the ibuprofen solubility and the amount of ethanol and ibuprofen encapsulated in the gelatin microcapsule were investigated. Ibuprofen solubility and the amount of ethanol encapsulated increased as gelatin and sodium lauryl sulfate increased, reached maximum at 4% and 0.6%, respectively and then followed a rapid decrease. Furthermore, the ibuprofen solubility and the encapsulated ibuprofen content increased as the amount of ibuprofen increased, reaching maximum at 0.5% and beyond that, there was no change in the solubility and ibuprofen content. However, the encapsulated ethanol content remained same irrespective of the amount of ibuprofen. On the basis of increased ibuprofen solubility, our results showed that the formula of ibuprofen-loaded gelatin microcapsule at the ratio of gelatin/ibuprofen sodium lauryl sulfate/water/ethanol of 4/0.5/0.6/30/70 with ibuprofen solubility of about 290㎍/mL and ethanol content of about 160㎍/mg could be a potential oral delivery system for poorly water-soluble ibuprofen.
URI
http://kiss.kstudy.com/thesis/thesis-view.asp?key=2698296http://repository.hanyang.ac.kr/handle/20.500.11754/107092
ISSN
2093-5552
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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