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Prions and prion diseases: Fundamentals and mechanistic details

Title
Prions and prion diseases: Fundamentals and mechanistic details
Author
류종석
Keywords
Prion disease; prion; PrPC; PrPSc; species barrier; conformational conversion; prion replication; prion pathogenesis
Issue Date
2007-07
Publisher
한국미생물생명공학회
Citation
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v. 17, No. 7, Page. 1059-1070
Abstract
Prion diseases, often called transmissible spongiformneurological dysfunctions in many mamalian hosts. Priondiseases include Creutzfeldt-Jakob disease (CJD) in humans,bovine spongiform encephalopathy (BSE, “mad cow disease”)in cattle, scrapie in shep, and chronic wasting disease(CWD) in deer and elks. The cause of these fatal diseases is aproteinaceous pathogen termed prion that lacks functionalnucleic acids. As demonstrated in the BSE outbreak and itstransmission to humans, the onset of disease is not limited to ato another. Such a striking nature of prions has generated hugeconcerns in public health and attracted serious attention in thescientific comunities. To date, the potential transmission of prionsto humans via foodborne infection and iatrogenic routes hasnot been alleviated. Rather, the posible transmission ofhuman to human or cervids to human aggravates the terrifyingsituation acros the globe. In this review, basic features aboutprion diseases including clinical and pathological characteristics,recently accumulated evidences, the molecular and biochemicalaspects of prions, with an emphasis on the molecular interactionsinvolved in prion conversion that is critical during prionreplication and pathogenesis, are also addresed.
URI
http://kiss.kstudy.com/thesis/thesis-view.asp?key=2627689http://repository.hanyang.ac.kr/handle/20.500.11754/106761
ISSN
1017-7825; 1738-8872
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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