Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2019-06-14T05:17:36Z | - |
dc.date.available | 2019-06-14T05:17:36Z | - |
dc.date.issued | 2007-07 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF PHARMACOLOGY, v. 567, No. 3, Page. 193-197 | en_US |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.issn | 1879-0712 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0014299907004645 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/106629 | - |
dc.description.abstract | Matrix rnetalloproteinases (MMPs) play important roles in solid tumor invasion and migration. In this study, we showed that 1-furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) dose-dependently inhibited HT1080 cell invasion and migration, and decreased NIMP-2 and MMP-9 activities. Furtherniore. FPP-3 reduced MMP-2 expression at protein and inRNA levels, and suppressed 12-0-tetradecanoylphorbol-13-acetate (TPA)enhanced expression of MTl-MMP without changing tissue inhibitors of rnetalloproteinase (TIMP)-2 level. FPP-3 also suppressed TPA-induced increases in MMP-9 protein and rnRNA levels, but did not alter TIMP-1 level. Our results suggest that FFP-3 may be a valuable anti-invasive drug candidate for cancer therapy by suppressing MMP-2, MMP-9, and MT1-MMP. (C) 2007 Elsevier B.V. All rights reserved. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | 1-furan-2-yl-3-pyridin-2-yl-propenone | en_US |
dc.subject | MMP-2 | en_US |
dc.subject | MMP-9 | en_US |
dc.subject | MT1-MMP | en_US |
dc.subject | TIMP | en_US |
dc.title | 1-furan-2-yl-3-pyridin-2-yl-propenone inhibits the invasion and migration of HT1080 human fibrosarcoma cells through the inhibition of proMMP-2 activation and down regulation of MMP-9 and MT1-MMP | en_US |
dc.type | Article | en_US |
dc.relation.volume | 567 | - |
dc.identifier.doi | 10.1016/j.ejphar.2007.04.014 | - |
dc.relation.page | 193-197 | - |
dc.relation.journal | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.contributor.googleauthor | Byung Chul, Park | - |
dc.contributor.googleauthor | Dinesh, Thapa | - |
dc.contributor.googleauthor | Yoon-Seok, Lee | - |
dc.contributor.googleauthor | Mi-Kyoung, Kwak | - |
dc.contributor.googleauthor | Eung-Seok, Lee | - |
dc.contributor.googleauthor | Han Gon, Choi | - |
dc.contributor.googleauthor | Chul Soon, Yong | - |
dc.contributor.googleauthor | Jung-Ae, Kim | - |
dc.relation.code | 2007203051 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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