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1-furan-2-yl-3-pyridin-2-yl-propenone inhibits the invasion and migration of HT1080 human fibrosarcoma cells through the inhibition of proMMP-2 activation and down regulation of MMP-9 and MT1-MMP

Title
1-furan-2-yl-3-pyridin-2-yl-propenone inhibits the invasion and migration of HT1080 human fibrosarcoma cells through the inhibition of proMMP-2 activation and down regulation of MMP-9 and MT1-MMP
Author
최한곤
Keywords
1-furan-2-yl-3-pyridin-2-yl-propenone; MMP-2; MMP-9; MT1-MMP; TIMP
Issue Date
2007-07
Publisher
ELSEVIER SCIENCE BV
Citation
EUROPEAN JOURNAL OF PHARMACOLOGY, v. 567, No. 3, Page. 193-197
Abstract
Matrix rnetalloproteinases (MMPs) play important roles in solid tumor invasion and migration. In this study, we showed that 1-furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) dose-dependently inhibited HT1080 cell invasion and migration, and decreased NIMP-2 and MMP-9 activities. Furtherniore. FPP-3 reduced MMP-2 expression at protein and inRNA levels, and suppressed 12-0-tetradecanoylphorbol-13-acetate (TPA)enhanced expression of MTl-MMP without changing tissue inhibitors of rnetalloproteinase (TIMP)-2 level. FPP-3 also suppressed TPA-induced increases in MMP-9 protein and rnRNA levels, but did not alter TIMP-1 level. Our results suggest that FFP-3 may be a valuable anti-invasive drug candidate for cancer therapy by suppressing MMP-2, MMP-9, and MT1-MMP. (C) 2007 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0014299907004645http://repository.hanyang.ac.kr/handle/20.500.11754/106629
ISSN
0014-2999; 1879-0712
DOI
10.1016/j.ejphar.2007.04.014
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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