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dc.contributor.author이철훈-
dc.date.accessioned2019-06-14T04:49:21Z-
dc.date.available2019-06-14T04:49:21Z-
dc.date.issued2007-06-
dc.identifier.citationCANCER SCIENCE, v. 98, No. 6, Page. 795-802en_US
dc.identifier.issn1347-9032-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/j.1349-7006.2007.00473.x-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/106623-
dc.description.abstractIn the course of screening for anticancer agents, a novel active compound, F3-2-5, was isolated from culture broth of Streptomyces sp., KACC91015. Its structure was identified using nuclear magnetic resonance, mass spectrometry, and molecular modeling experiments, and confirmed by total synthesis. The growth of various human cancer cell lines was inhibited in a dose-dependent manner by 0.06-0.48 mM F3-2-5 over 24 h. Its IC50 values were estimated at 37 mu M on HeLa, 72 mu M on A549, and 190 mu M on HT-29 cells. However, F3-2-5 had no antiproliferative effect on normal lymphocytes and normal fibroblasts used as controls. Moreover, it affected cell cycle regulation and caused apoptosis of the HeLa cellsen_US
dc.description.sponsorshipThis work was supported by Biogreen 21 (Korea Ministry of Agriculture and Forestry) and the second Brain Korea 21 (Korea Ministry of Education) grants.en_US
dc.language.isoen_USen_US
dc.publisherBLACKWELL PUBLISHINGen_US
dc.subjectDEPENDENT KINASE INHIBITORen_US
dc.subjectCDK INHIBITORSen_US
dc.subjectRETINOBLASTOMA PROTEINen_US
dc.subjectBAUHINIA-FORFICATAen_US
dc.subjectPOTENTIAL MEDIATORen_US
dc.subjectCYTOCHROME-Cen_US
dc.subjectP53en_US
dc.subjectPHOSPHORYLATIONen_US
dc.subjectMITOCHONDRIAen_US
dc.subjectCANCERen_US
dc.titleNovel anticancer agent, benzyldihydroxyoctenone, isolated from Streptomyces sp causes G(1) cell cycle arrest and induces apoptosis of HeLa cellsen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/j.1349-7006.2007.00473.x-
dc.relation.journalCANCER SCIENCE-
dc.contributor.googleauthorLee, Chul-Hoon-
dc.contributor.googleauthorLim, Haeyoung-
dc.contributor.googleauthorMoon, Sangik-
dc.contributor.googleauthorShin, Choonshik-
dc.contributor.googleauthorKim, Seunghyun-
dc.contributor.googleauthorKim, Bum-Joon-
dc.contributor.googleauthorLim, Yoongho-
dc.relation.code2007211563-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidchhlee-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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