34 0

Novel anticancer agent, benzyldihydroxyoctenone, isolated from Streptomyces sp causes G(1) cell cycle arrest and induces apoptosis of HeLa cells

Title
Novel anticancer agent, benzyldihydroxyoctenone, isolated from Streptomyces sp causes G(1) cell cycle arrest and induces apoptosis of HeLa cells
Author
이철훈
Keywords
DEPENDENT KINASE INHIBITOR; CDK INHIBITORS; RETINOBLASTOMA PROTEIN; BAUHINIA-FORFICATA; POTENTIAL MEDIATOR; CYTOCHROME-C; P53; PHOSPHORYLATION; MITOCHONDRIA; CANCER
Issue Date
2007-06
Publisher
BLACKWELL PUBLISHING
Citation
CANCER SCIENCE, v. 98, No. 6, Page. 795-802
Abstract
In the course of screening for anticancer agents, a novel active compound, F3-2-5, was isolated from culture broth of Streptomyces sp., KACC91015. Its structure was identified using nuclear magnetic resonance, mass spectrometry, and molecular modeling experiments, and confirmed by total synthesis. The growth of various human cancer cell lines was inhibited in a dose-dependent manner by 0.06-0.48 mM F3-2-5 over 24 h. Its IC50 values were estimated at 37 mu M on HeLa, 72 mu M on A549, and 190 mu M on HT-29 cells. However, F3-2-5 had no antiproliferative effect on normal lymphocytes and normal fibroblasts used as controls. Moreover, it affected cell cycle regulation and caused apoptosis of the HeLa cells
URI
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1349-7006.2007.00473.xhttp://repository.hanyang.ac.kr/handle/20.500.11754/106623
ISSN
1347-9032
DOI
10.1111/j.1349-7006.2007.00473.x
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE