Novel anticancer agent, benzyldihydroxyoctenone, isolated from Streptomyces sp causes G(1) cell cycle arrest and induces apoptosis of HeLa cells
- Title
- Novel anticancer agent, benzyldihydroxyoctenone, isolated from Streptomyces sp causes G(1) cell cycle arrest and induces apoptosis of HeLa cells
- Author
- 이철훈
- Keywords
- DEPENDENT KINASE INHIBITOR; CDK INHIBITORS; RETINOBLASTOMA PROTEIN; BAUHINIA-FORFICATA; POTENTIAL MEDIATOR; CYTOCHROME-C; P53; PHOSPHORYLATION; MITOCHONDRIA; CANCER
- Issue Date
- 2007-06
- Publisher
- BLACKWELL PUBLISHING
- Citation
- CANCER SCIENCE, v. 98, No. 6, Page. 795-802
- Abstract
- In the course of screening for anticancer agents, a novel active compound, F3-2-5, was isolated from culture broth of Streptomyces sp., KACC91015. Its structure was identified using nuclear magnetic resonance, mass spectrometry, and molecular modeling experiments, and confirmed by total synthesis. The growth of various human cancer cell lines was inhibited in a dose-dependent manner by 0.06-0.48 mM F3-2-5 over 24 h. Its IC50 values were estimated at 37 mu M on HeLa, 72 mu M on A549, and 190 mu M on HT-29 cells. However, F3-2-5 had no antiproliferative effect on normal lymphocytes and normal fibroblasts used as controls. Moreover, it affected cell cycle regulation and caused apoptosis of the HeLa cells
- URI
- https://onlinelibrary.wiley.com/doi/full/10.1111/j.1349-7006.2007.00473.xhttps://repository.hanyang.ac.kr/handle/20.500.11754/106623
- ISSN
- 1347-9032
- DOI
- 10.1111/j.1349-7006.2007.00473.x
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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