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Short communication: In vivo evaluation of microemulsion system for oral and parenteral delivery of rutaecarpine to rats

Title
Short communication: In vivo evaluation of microemulsion system for oral and parenteral delivery of rutaecarpine to rats
Author
최한곤
Keywords
microemulsion; rutaecarpine; pharmacokinetics
Issue Date
2007-05
Publisher
TAYLOR & FRANCIS INC
Citation
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, v. 33, No. 5, Page. 531-534
Abstract
Rutaecarpine-loaded microemulsion composed of 10.8% polyethylene glycol 400, 7.2% Tween 80, 20% caster oil, and 62% water were previously reported to be physically and chemically stable for at least 6 months. For the development of a Rutaecarpine-loaded microemulsion, here we studied the pharmacokinetic profiles of rutaecarpine after oral and intravenous administration of rutaecarpine-loaded microemulsion compared to suspension. The AUC of rutaecarpine from microemulsion after oral and intravenous administration increased about three-fold compared with that from suspension. Furthermore, the rutaecarpine-loaded microemulsion gave significantly higher AUC and C-max than did suspension, suggesting that the oral bioavailability of rutaecarpine in this microemulsion system could be enhanced due to the enhanced solubility of rutaecarpine by microemulsion. Thus, our results indicated that the microemulsion system composed of castor oil, polyethylene glycol 400, Tween 80, and water could be a more effective oral and parenteral dosage form for rutaecarpine.
URI
https://www.tandfonline.com/doi/full/10.1080/03639040600865199http://repository.hanyang.ac.kr/handle/20.500.11754/106498
ISSN
0363-9045
DOI
10.1080/03639040600865199
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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