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dc.contributor.author김은진-
dc.date.accessioned2019-05-27T04:10:04Z-
dc.date.available2019-05-27T04:10:04Z-
dc.date.issued2015-04-
dc.identifier.citationCLINICAL AND VACCINE IMMUNOLOGY, v. 22, No. 4, Page. 381-388en_US
dc.identifier.issn1556-6811-
dc.identifier.issn1556-679X-
dc.identifier.urihttps://cvi.asm.org/content/22/4/381.short-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/105990-
dc.description.abstractIn developing countries, Shigella is a primary cause of diarrhea in infants and young children. Although antibiotic therapy is an effective treatment for shigellosis, therapeutic options are narrowing due to the emergence of antibiotic resistance. Thus, preventive vaccination could become the most efficacious approach for controlling shigellosis. We have identified several conserved protein antigens that are shared by multiple Shigella serotypes and species. Among these, one antigen induced cross-protection against experimental shigellosis, and we have named it pan-Shigella surface protein 1 (PSSP-1). PSSP-1-induced protection requires a mucosal administration route and coadministration of an adjuvant. When PSSP-1 was administered intranasally, it induced cross-protection against Shigella flexneri serotypes 2a, 5a, and 6, Shigella boydii, Shigella sonnei, and Shigella dysenteriae serotype 1. Intradermally administered PSSP-1 induced strong serum antibody responses but failed to induce protection in the mouse lung pneumonia model. In contrast, intranasal administration elicited efficient local and systemic antibody responses and production of interleukin 17A and gamma interferon. Interestingly, blood samples from patients with recent-onset shigellosis showed variable but significant mucosal antibody responses to other conserved Shigella protein antigens but not to PSSP-1. We suggest that PSSP-1 is a promising antigen for a broadly protective vaccine against Shigella.en_US
dc.description.sponsorshipThis work was supported by grants from the National Research Foundation of Korea (grants NRF-2013K1A2A1058637 and NRF-2013K1A2A1058645), PATH (PSSP-1 SUBVACS against Dysentery Preclinical and Early Clinical Development), and the governments of the Republic of Korea and Sweden. D.W.K. was supported by grant 2012R1A2A2A01009741 from the National Research Foundation of Korea.en_US
dc.language.isoen_USen_US
dc.publisherAMER SOC MICROBIOLOGYen_US
dc.subjectESCHERICHIA-COLIen_US
dc.subjectIMMUNE-RESPONSESen_US
dc.subjectGENOME SEQUENCEen_US
dc.subjectCHAIN-LENGTHen_US
dc.subjectFLEXNERI 2Aen_US
dc.subjectANTIGENen_US
dc.subjectVIRULENCEen_US
dc.subjectICSAen_US
dc.subjectVIRGen_US
dc.subjectLIPOPOLYSACCHARIDEen_US
dc.titleShigella Outer Membrane Protein PSSP-1 Is Broadly Protective against Shigella Infectionen_US
dc.typeArticleen_US
dc.relation.volume22-
dc.identifier.doi10.1128/CVI.00661-14-
dc.relation.page381-388-
dc.relation.journalCLINICAL AND VACCINE IMMUNOLOGY-
dc.contributor.googleauthorKim, Jae-Ouk-
dc.contributor.googleauthorRho, Semi-
dc.contributor.googleauthorKim, Su Hee-
dc.contributor.googleauthorKim, Heejoo-
dc.contributor.googleauthorSong, Hyo Jin-
dc.contributor.googleauthorKim, Eun Jin-
dc.contributor.googleauthorKim, Ryang Yeo-
dc.contributor.googleauthorKim, Eun Hye-
dc.contributor.googleauthorSinha, Anuradha-
dc.contributor.googleauthorDey, Ayan-
dc.contributor.googleauthorYang, Jae Seung-
dc.contributor.googleauthorSong, Man Ki-
dc.contributor.googleauthorNandy, Ranjan Kumar-
dc.contributor.googleauthorCzerkinsky, Cecil-
dc.contributor.googleauthorKim, Dong Wook-
dc.relation.code2015003413-
dc.sector.campusE-
dc.sector.daehakINDUSTRY-UNIVERSITY COOPERATION FOUNDATION(ERICA)[E]-
dc.sector.departmentRESEARCH INSTITUTE-
dc.identifier.pidejkim0816-
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