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Shigella Outer Membrane Protein PSSP-1 Is Broadly Protective against Shigella Infection

Title
Shigella Outer Membrane Protein PSSP-1 Is Broadly Protective against Shigella Infection
Author
김은진
Keywords
ESCHERICHIA-COLI; IMMUNE-RESPONSES; GENOME SEQUENCE; CHAIN-LENGTH; FLEXNERI 2A; ANTIGEN; VIRULENCE; ICSA; VIRG; LIPOPOLYSACCHARIDE
Issue Date
2015-04
Publisher
AMER SOC MICROBIOLOGY
Citation
CLINICAL AND VACCINE IMMUNOLOGY, v. 22, No. 4, Page. 381-388
Abstract
In developing countries, Shigella is a primary cause of diarrhea in infants and young children. Although antibiotic therapy is an effective treatment for shigellosis, therapeutic options are narrowing due to the emergence of antibiotic resistance. Thus, preventive vaccination could become the most efficacious approach for controlling shigellosis. We have identified several conserved protein antigens that are shared by multiple Shigella serotypes and species. Among these, one antigen induced cross-protection against experimental shigellosis, and we have named it pan-Shigella surface protein 1 (PSSP-1). PSSP-1-induced protection requires a mucosal administration route and coadministration of an adjuvant. When PSSP-1 was administered intranasally, it induced cross-protection against Shigella flexneri serotypes 2a, 5a, and 6, Shigella boydii, Shigella sonnei, and Shigella dysenteriae serotype 1. Intradermally administered PSSP-1 induced strong serum antibody responses but failed to induce protection in the mouse lung pneumonia model. In contrast, intranasal administration elicited efficient local and systemic antibody responses and production of interleukin 17A and gamma interferon. Interestingly, blood samples from patients with recent-onset shigellosis showed variable but significant mucosal antibody responses to other conserved Shigella protein antigens but not to PSSP-1. We suggest that PSSP-1 is a promising antigen for a broadly protective vaccine against Shigella.
URI
https://cvi.asm.org/content/22/4/381.shorthttp://repository.hanyang.ac.kr/handle/20.500.11754/105990
ISSN
1556-6811; 1556-679X
DOI
10.1128/CVI.00661-14
Appears in Collections:
ETC > 연구정보
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