Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이항락 | - |
dc.date.accessioned | 2019-05-23T06:45:01Z | - |
dc.date.available | 2019-05-23T06:45:01Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.citation | JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, v. 23, no. 1, page. 109-116 | en_US |
dc.identifier.issn | 2093-0879 | - |
dc.identifier.issn | 2093-0887 | - |
dc.identifier.uri | http://www.jnmjournal.org/journal/view.html?doi=10.5056/jnm16003 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/105939 | - |
dc.description.abstract | Background/AimsPost-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain. The aim of this study was to investigate whether DA-9701 can ameliorate POI in rats.MethodsA total of 32 rats were divided into 4 groups: no surgery/no medication (NSNM), no surgery/medication (NSM), surgery/no medication (SNM), and surgery/medication (SM). Gastrointestinal transit (GIT), which is assessed by migration of charcoal, and cumulative stool weight were measured at 24 hours after surgery.ResultsGIT was significantly more delayed in the SNM group than in the other groups (SNM vs NSNM, P < 0.001; SNM vs NSM, P < 0.001; SNM vs SM, P = 0.005). Cumulative stool weight in that group was also lower than in the no surgery groups (SNM vs NSNM, P = 0.007; SNM vs NSM, P = 0.033), and there was no significant difference between the SM group and the no surgery groups (SM vs NSM, P = 0.703; SM vs NSNM, P = 0.347).ConclusionDA-9701 can ameliorate POI by reducing delayed GIT and improving defecation in a rat model of POI. | en_US |
dc.description.sponsorship | This study was supported by Dong-A Pharmaceutical Company, Seoul, Korea, the manufacturer of DA-9701 (Grant No. 1-1312011). The funding source had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN SOC NEUROGASTROENTEROLOGY & MOTILITY | en_US |
dc.subject | Corydalis | en_US |
dc.subject | DA-9701 | en_US |
dc.subject | Gastrointestinal transit | en_US |
dc.subject | Ghrelin | en_US |
dc.subject | Ileus | en_US |
dc.title | Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 23 | - |
dc.identifier.doi | 10.5056/jnm16003 | - |
dc.relation.page | 109-116 | - |
dc.relation.journal | JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY | - |
dc.contributor.googleauthor | Lee, Sang Pyo | - |
dc.contributor.googleauthor | Lee, Oh Young | - |
dc.contributor.googleauthor | Lee, Kang Nyeong | - |
dc.contributor.googleauthor | Lee, Hang Lak | - |
dc.contributor.googleauthor | Choi, Ho Soon | - |
dc.contributor.googleauthor | Yoon, Byung Chul | - |
dc.contributor.googleauthor | Jun, Dae Won | - |
dc.relation.code | 2017011618 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | alwayshang | - |
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