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dc.contributor.author이항락-
dc.date.accessioned2019-05-23T06:45:01Z-
dc.date.available2019-05-23T06:45:01Z-
dc.date.issued2017-01-
dc.identifier.citationJOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, v. 23, no. 1, page. 109-116en_US
dc.identifier.issn2093-0879-
dc.identifier.issn2093-0887-
dc.identifier.urihttp://www.jnmjournal.org/journal/view.html?doi=10.5056/jnm16003-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/105939-
dc.description.abstractBackground/AimsPost-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain. The aim of this study was to investigate whether DA-9701 can ameliorate POI in rats.MethodsA total of 32 rats were divided into 4 groups: no surgery/no medication (NSNM), no surgery/medication (NSM), surgery/no medication (SNM), and surgery/medication (SM). Gastrointestinal transit (GIT), which is assessed by migration of charcoal, and cumulative stool weight were measured at 24 hours after surgery.ResultsGIT was significantly more delayed in the SNM group than in the other groups (SNM vs NSNM, P < 0.001; SNM vs NSM, P < 0.001; SNM vs SM, P = 0.005). Cumulative stool weight in that group was also lower than in the no surgery groups (SNM vs NSNM, P = 0.007; SNM vs NSM, P = 0.033), and there was no significant difference between the SM group and the no surgery groups (SM vs NSM, P = 0.703; SM vs NSNM, P = 0.347).ConclusionDA-9701 can ameliorate POI by reducing delayed GIT and improving defecation in a rat model of POI.en_US
dc.description.sponsorshipThis study was supported by Dong-A Pharmaceutical Company, Seoul, Korea, the manufacturer of DA-9701 (Grant No. 1-1312011). The funding source had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.en_US
dc.language.isoenen_US
dc.publisherKOREAN SOC NEUROGASTROENTEROLOGY & MOTILITYen_US
dc.subjectCorydalisen_US
dc.subjectDA-9701en_US
dc.subjectGastrointestinal transiten_US
dc.subjectGhrelinen_US
dc.subjectIleusen_US
dc.titleEffect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Ratsen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume23-
dc.identifier.doi10.5056/jnm16003-
dc.relation.page109-116-
dc.relation.journalJOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY-
dc.contributor.googleauthorLee, Sang Pyo-
dc.contributor.googleauthorLee, Oh Young-
dc.contributor.googleauthorLee, Kang Nyeong-
dc.contributor.googleauthorLee, Hang Lak-
dc.contributor.googleauthorChoi, Ho Soon-
dc.contributor.googleauthorYoon, Byung Chul-
dc.contributor.googleauthorJun, Dae Won-
dc.relation.code2017011618-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidalwayshang-


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