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Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats

Title
Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats
Author
이항락
Keywords
Corydalis; DA-9701; Gastrointestinal transit; Ghrelin; Ileus
Issue Date
2017-01
Publisher
KOREAN SOC NEUROGASTROENTEROLOGY & MOTILITY
Citation
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, v. 23, no. 1, page. 109-116
Abstract
Background/AimsPost-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain. The aim of this study was to investigate whether DA-9701 can ameliorate POI in rats.MethodsA total of 32 rats were divided into 4 groups: no surgery/no medication (NSNM), no surgery/medication (NSM), surgery/no medication (SNM), and surgery/medication (SM). Gastrointestinal transit (GIT), which is assessed by migration of charcoal, and cumulative stool weight were measured at 24 hours after surgery.ResultsGIT was significantly more delayed in the SNM group than in the other groups (SNM vs NSNM, P < 0.001; SNM vs NSM, P < 0.001; SNM vs SM, P = 0.005). Cumulative stool weight in that group was also lower than in the no surgery groups (SNM vs NSNM, P = 0.007; SNM vs NSM, P = 0.033), and there was no significant difference between the SM group and the no surgery groups (SM vs NSM, P = 0.703; SM vs NSNM, P = 0.347).ConclusionDA-9701 can ameliorate POI by reducing delayed GIT and improving defecation in a rat model of POI.
URI
http://www.jnmjournal.org/journal/view.html?doi=10.5056/jnm16003http://repository.hanyang.ac.kr/handle/20.500.11754/105939
ISSN
2093-0879; 2093-0887
DOI
10.5056/jnm16003
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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