Continuous O2-evolving MnFe2O4 nanoparticle-anchored mesoporous silica nanoparticles for efficient photodynamic therapy in hypoxic cancer
- Title
- Continuous O2-evolving MnFe2O4 nanoparticle-anchored mesoporous silica nanoparticles for efficient photodynamic therapy in hypoxic cancer
- Author
- 김도균
- Keywords
- MANGANESE FERRITE NANOPARTICLES; TUMOR OXYGENATION; FENTON REACTION; IN-VIVO; CELLS; CHEMOTHERAPY; ENHANCE; RESISTANCE; DOTS
- Issue Date
- 2017-08
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v. 139, No. 32, Page. 10992-10995
- Abstract
- Therapeutic effects of photodynamic therapy (PDT) are limited by cancer hypoxia because the PDT process is dependent on O-2 concentration. Herein, we design biocompatible manganese ferrite nanoparticle-anchored mesoporous silica nanoparticles (MFMSNs) to overcome hypoxia, consequently enhancing the therapeutic efficiency of PDT. By exploiting the continuous O-2-evolving property of MnFe2O4 nanoparticles through the Fenton reaction, MFMSNs relieve hypoxic condition using a small amount of nanoparticles and improve therapeutic outcomes of PDT for tumors in vivo. In addition, MFMSNs exhibit T-2 contrast effect in magnetic resonance imaging (MRI), allowing in vivo tracking of MFMSNs. These findings demonstrate great potential of MFMSNs for theranostic agents in cancer therapy.
- URI
- https://pubs.acs.org/doi/abs/10.1021/jacs.7b05559https://repository.hanyang.ac.kr/handle/20.500.11754/105871
- ISSN
- 0002-7863
- DOI
- 10.1021/jacs.7b05559
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > BIONANO ENGINEERING(생명나노공학과) > Articles
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