20 0

Total Synthesis and Biological Evaluation of Sericetin for Protection against Cisplatin-Induced Acute Kidney Injury

Title
Total Synthesis and Biological Evaluation of Sericetin for Protection against Cisplatin-Induced Acute Kidney Injury
Author
배옥남
Keywords
PRENYLATED FLAVONOIDS; INDUCED NEPHROTOXICITY; OXIDATIVE STRESS; MACAKURZIN C; CELL-DEATH; IN-VITRO; INFLAMMATION; INHIBITION; MECHANISMS; APOPTOSIS
Issue Date
2018-12
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF NATURAL PRODUCTS, v. 81, No. 12, Page. 2647-2653
Abstract
A concise synthesis of sericetin (1) was performed in four steps from readily available 3-Obenzylgalangin (4), featuring electrocyclization to produce the tricyclic core and a sequential aromatic Claisen/Cope rearrangement to incorporate the 8-prenyl group of 1. In addition, the therapeutic potential of sericetin (1), isosericetin (2), and three prenylated tetracyclic synthetic intermediates (11, 12, and 14) against cisplatin-induced nephrotoxicity using renal tubular cells were evaluated. Compound 14 showed therapeutic potential against cisplatin-induced kidney damage.
URI
https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.8b00434http://repository.hanyang.ac.kr/handle/20.500.11754/105798
ISSN
0163-3864; 1520-6025
DOI
10.1021/acs.jnatprod.8b00434
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE