Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 류종석 | - |
dc.date.accessioned | 2019-05-23T02:01:30Z | - |
dc.date.available | 2019-05-23T02:01:30Z | - |
dc.date.issued | 2018-12 | - |
dc.identifier.citation | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v. 28, No. 12, Page. 2141-2144 | en_US |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.issn | 1738-8872 | - |
dc.identifier.uri | http://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.1807.07045 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/105791 | - |
dc.description.abstract | Based on previous studies reporting the anti-prion activity of poly-L-lysine and poly-L-arginine, we investigated cationic poly-L-ornithine (PLO), poly-L-histidine (PLH), anionic poly-L-glutamic acid (PLE) and uncharged poly-L-threonine (PLT) in cultured cells chronically infected by prions to determine their anti-prion efficacy. While PLE and PLT did not alter the level of PrPSc, PLO and PLH exhibited potent PrP Sc inhibition in ScN2a cells. These results suggest that the anti-prion activity of poly-basic amino acids is correlated with the cationicity of their functional groups. Comparison of anti-prion activity of PLO and PLH proposes that the anti-prion activity of poly-basic amino acids is associated with their acidic cellular compartments. | en_US |
dc.description.sponsorship | This work was supported by the research fund of Hanyang University (HY-2014-P) | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY | en_US |
dc.subject | Prion | en_US |
dc.subject | polyornithine | en_US |
dc.subject | polyhistidine | en_US |
dc.subject | cationic amino acid polymer | en_US |
dc.title | Decrease of protease-resistant PrPSc level in ScN2a cells by polyornithine and polyhistidine | en_US |
dc.type | Article | en_US |
dc.relation.volume | 28 | - |
dc.identifier.doi | 10.4014/jmb.1807.07045 | - |
dc.relation.page | 2141-2144 | - |
dc.relation.journal | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.contributor.googleauthor | Waqas, Muhammad | - |
dc.contributor.googleauthor | Trinh, Huyen Trang | - |
dc.contributor.googleauthor | Lee, Sungeun | - |
dc.contributor.googleauthor | Kim, Dae-Hwan | - |
dc.contributor.googleauthor | Lee, Sang Yeol | - |
dc.contributor.googleauthor | Choe, Kevin K. | - |
dc.contributor.googleauthor | Ryou, Chongsuk | - |
dc.relation.code | 2018006087 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | cryou2 | - |
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