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dc.contributor.author류종석-
dc.date.accessioned2019-05-23T02:01:30Z-
dc.date.available2019-05-23T02:01:30Z-
dc.date.issued2018-12-
dc.identifier.citationJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v. 28, No. 12, Page. 2141-2144en_US
dc.identifier.issn1017-7825-
dc.identifier.issn1738-8872-
dc.identifier.urihttp://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.1807.07045-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/105791-
dc.description.abstractBased on previous studies reporting the anti-prion activity of poly-L-lysine and poly-L-arginine, we investigated cationic poly-L-ornithine (PLO), poly-L-histidine (PLH), anionic poly-L-glutamic acid (PLE) and uncharged poly-L-threonine (PLT) in cultured cells chronically infected by prions to determine their anti-prion efficacy. While PLE and PLT did not alter the level of PrPSc, PLO and PLH exhibited potent PrP Sc inhibition in ScN2a cells. These results suggest that the anti-prion activity of poly-basic amino acids is correlated with the cationicity of their functional groups. Comparison of anti-prion activity of PLO and PLH proposes that the anti-prion activity of poly-basic amino acids is associated with their acidic cellular compartments.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-2014-P)en_US
dc.language.isoen_USen_US
dc.publisherKOREAN SOC MICROBIOLOGY & BIOTECHNOLOGYen_US
dc.subjectPrionen_US
dc.subjectpolyornithineen_US
dc.subjectpolyhistidineen_US
dc.subjectcationic amino acid polymeren_US
dc.titleDecrease of protease-resistant PrPSc level in ScN2a cells by polyornithine and polyhistidineen_US
dc.typeArticleen_US
dc.relation.volume28-
dc.identifier.doi10.4014/jmb.1807.07045-
dc.relation.page2141-2144-
dc.relation.journalJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY-
dc.contributor.googleauthorWaqas, Muhammad-
dc.contributor.googleauthorTrinh, Huyen Trang-
dc.contributor.googleauthorLee, Sungeun-
dc.contributor.googleauthorKim, Dae-Hwan-
dc.contributor.googleauthorLee, Sang Yeol-
dc.contributor.googleauthorChoe, Kevin K.-
dc.contributor.googleauthorRyou, Chongsuk-
dc.relation.code2018006087-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidcryou2-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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