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Decrease of protease-resistant PrPSc level in ScN2a cells by polyornithine and polyhistidine

Title
Decrease of protease-resistant PrPSc level in ScN2a cells by polyornithine and polyhistidine
Author
류종석
Keywords
Prion; polyornithine; polyhistidine; cationic amino acid polymer
Issue Date
2018-12
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
Citation
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v. 28, No. 12, Page. 2141-2144
Abstract
Based on previous studies reporting the anti-prion activity of poly-L-lysine and poly-L-arginine, we investigated cationic poly-L-ornithine (PLO), poly-L-histidine (PLH), anionic poly-L-glutamic acid (PLE) and uncharged poly-L-threonine (PLT) in cultured cells chronically infected by prions to determine their anti-prion efficacy. While PLE and PLT did not alter the level of PrPSc, PLO and PLH exhibited potent PrP Sc inhibition in ScN2a cells. These results suggest that the anti-prion activity of poly-basic amino acids is correlated with the cationicity of their functional groups. Comparison of anti-prion activity of PLO and PLH proposes that the anti-prion activity of poly-basic amino acids is associated with their acidic cellular compartments.
URI
http://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.1807.07045http://repository.hanyang.ac.kr/handle/20.500.11754/105791
ISSN
1017-7825; 1738-8872
DOI
10.4014/jmb.1807.07045
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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