46 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author문효방-
dc.date.accessioned2019-05-23T01:42:20Z-
dc.date.available2019-05-23T01:42:20Z-
dc.date.issued2018-10-
dc.identifier.citationCANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, v. 27, No. 10, Page. 1159-1167en_US
dc.identifier.issn1055-9965-
dc.identifier.urihttp://cebp.aacrjournals.org/content/27/10/1159.abstract-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/105771-
dc.description.abstractBackground: T-cell immunosenescence, a hallmark of an aging immune system, is potentially linked to the risk of developing cancer and other aging-related diseases. Chronic infection by cytomegalovirus (CMV) has been widely studied as a risk factor for T-cell immunosenescence, but the role of persistent chemicals has never been examined. As a typical example of persistent chemicals, we evaluated whether organochlorine pesticides (OCPs) are related to T-cell immunosenescence in the general population. Methods: Serum concentrations of beta-hexachlorocyclohexane, p,p'-DDT, p,p'-DDE, and trans-nonachlor were measured in 95 Korean adults ages 30 to 64 years. T-cell immunosenescence was assessed by the frequencies of CD8(+)CD57(+), CD8(+)CD28(-), CD4(+)CD57(+), and CD4(+)CD28(-) T lymphocytes in 20 mL of fresh peripheral blood. Results: The senescence of CD8(+) T lymphocytes was the most consistently associated with OCPs. For quartiles of measurements of OCPs, adjusted mean percentages of CD8(+)CD57(+) and CD8(+)CD28(-) T lymphocytes in the CD8(+) T lymphocyte population were 23.9, 27.6, 31.0, and 38.7 (P-trend ˂ 0.01) and 25.6, 27.3, 28.0, and 35.5 (P-trend = 0.02), respectively. When we compared the strength of the associations among OCPs, CMV IgG titer, and age, OCPs showed the strongest association with markers of immunosenescence. Importantly, the association between OCPs and immunosenescence markers was more prominent among participants without known risk factors, such as a young age or low CMV immunoglobulin G titer. Conclusions: Chronic exposure to low-dose OCPs may be a new risk factor for T-cell immunosenescence. Impact: T-cell immunosenescence may be one possible mechanism linking low-dose OCPs and many chronic diseases. (C) 2018 AACR.en_US
dc.description.sponsorshipThis study was supported by The Korean Health Technology R&D Project (HI13C0715), funded by the Ministry of Health and Welfare of the Republic of Korea. The recipients of the grant are D.H. Lee, H.C. Kim, D.J. Kim, and E.C. Shinen_US
dc.language.isoen_USen_US
dc.publisherAMER ASSOC CANCER RESEARCHen_US
dc.subjectPERSISTENT ORGANIC POLLUTANTSen_US
dc.subjectPOLYCHLORINATED-BIPHENYLSen_US
dc.subjectCD28 EXPRESSIONen_US
dc.subjectCD8(+) CD28(-)en_US
dc.subjectIMMUNOTOXICITYen_US
dc.subjectCHEMICALSen_US
dc.subjectSURVIVALen_US
dc.subjectDISEASEen_US
dc.subjectHEALTHen_US
dc.subjectCANCERen_US
dc.titleIs Chronic Exposure to Low-Dose Organochlorine Pesticides a New Risk Factor of T-cell Immunosenescence?en_US
dc.typeArticleen_US
dc.relation.no10-
dc.relation.volume27-
dc.identifier.doi10.1158/1055-9965.EPI-17-0799-
dc.relation.page1159-1167-
dc.relation.journalCANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION-
dc.contributor.googleauthorRyu, Dong-Hee-
dc.contributor.googleauthorYu, Hee Tae-
dc.contributor.googleauthorKim, Se-A-
dc.contributor.googleauthorLee, Yu-Mi-
dc.contributor.googleauthorHong, Seon-Hui-
dc.contributor.googleauthorYoon, Young-Ran-
dc.contributor.googleauthorKim, Dae-Jung-
dc.contributor.googleauthorKim, Hyeon-Chang-
dc.contributor.googleauthorMoon, Hyo-Bang-
dc.contributor.googleauthorShin, Eui-Cheol-
dc.contributor.googleauthorLee, Duk-Hee-
dc.relation.code2018002267-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E]-
dc.sector.departmentDEPARTMENT OF MARINE SCIENCE AND CONVERGENCE ENGINEERING-
dc.identifier.pidhbmoon-


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE