Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 문효방 | - |
dc.date.accessioned | 2019-05-23T01:42:20Z | - |
dc.date.available | 2019-05-23T01:42:20Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, v. 27, No. 10, Page. 1159-1167 | en_US |
dc.identifier.issn | 1055-9965 | - |
dc.identifier.uri | http://cebp.aacrjournals.org/content/27/10/1159.abstract | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/105771 | - |
dc.description.abstract | Background: T-cell immunosenescence, a hallmark of an aging immune system, is potentially linked to the risk of developing cancer and other aging-related diseases. Chronic infection by cytomegalovirus (CMV) has been widely studied as a risk factor for T-cell immunosenescence, but the role of persistent chemicals has never been examined. As a typical example of persistent chemicals, we evaluated whether organochlorine pesticides (OCPs) are related to T-cell immunosenescence in the general population. Methods: Serum concentrations of beta-hexachlorocyclohexane, p,p'-DDT, p,p'-DDE, and trans-nonachlor were measured in 95 Korean adults ages 30 to 64 years. T-cell immunosenescence was assessed by the frequencies of CD8(+)CD57(+), CD8(+)CD28(-), CD4(+)CD57(+), and CD4(+)CD28(-) T lymphocytes in 20 mL of fresh peripheral blood. Results: The senescence of CD8(+) T lymphocytes was the most consistently associated with OCPs. For quartiles of measurements of OCPs, adjusted mean percentages of CD8(+)CD57(+) and CD8(+)CD28(-) T lymphocytes in the CD8(+) T lymphocyte population were 23.9, 27.6, 31.0, and 38.7 (P-trend ˂ 0.01) and 25.6, 27.3, 28.0, and 35.5 (P-trend = 0.02), respectively. When we compared the strength of the associations among OCPs, CMV IgG titer, and age, OCPs showed the strongest association with markers of immunosenescence. Importantly, the association between OCPs and immunosenescence markers was more prominent among participants without known risk factors, such as a young age or low CMV immunoglobulin G titer. Conclusions: Chronic exposure to low-dose OCPs may be a new risk factor for T-cell immunosenescence. Impact: T-cell immunosenescence may be one possible mechanism linking low-dose OCPs and many chronic diseases. (C) 2018 AACR. | en_US |
dc.description.sponsorship | This study was supported by The Korean Health Technology R&D Project (HI13C0715), funded by the Ministry of Health and Welfare of the Republic of Korea. The recipients of the grant are D.H. Lee, H.C. Kim, D.J. Kim, and E.C. Shin | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | AMER ASSOC CANCER RESEARCH | en_US |
dc.subject | PERSISTENT ORGANIC POLLUTANTS | en_US |
dc.subject | POLYCHLORINATED-BIPHENYLS | en_US |
dc.subject | CD28 EXPRESSION | en_US |
dc.subject | CD8(+) CD28(-) | en_US |
dc.subject | IMMUNOTOXICITY | en_US |
dc.subject | CHEMICALS | en_US |
dc.subject | SURVIVAL | en_US |
dc.subject | DISEASE | en_US |
dc.subject | HEALTH | en_US |
dc.subject | CANCER | en_US |
dc.title | Is Chronic Exposure to Low-Dose Organochlorine Pesticides a New Risk Factor of T-cell Immunosenescence? | en_US |
dc.type | Article | en_US |
dc.relation.no | 10 | - |
dc.relation.volume | 27 | - |
dc.identifier.doi | 10.1158/1055-9965.EPI-17-0799 | - |
dc.relation.page | 1159-1167 | - |
dc.relation.journal | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | - |
dc.contributor.googleauthor | Ryu, Dong-Hee | - |
dc.contributor.googleauthor | Yu, Hee Tae | - |
dc.contributor.googleauthor | Kim, Se-A | - |
dc.contributor.googleauthor | Lee, Yu-Mi | - |
dc.contributor.googleauthor | Hong, Seon-Hui | - |
dc.contributor.googleauthor | Yoon, Young-Ran | - |
dc.contributor.googleauthor | Kim, Dae-Jung | - |
dc.contributor.googleauthor | Kim, Hyeon-Chang | - |
dc.contributor.googleauthor | Moon, Hyo-Bang | - |
dc.contributor.googleauthor | Shin, Eui-Cheol | - |
dc.contributor.googleauthor | Lee, Duk-Hee | - |
dc.relation.code | 2018002267 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF MARINE SCIENCE AND CONVERGENCE ENGINEERING | - |
dc.identifier.pid | hbmoon | - |
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