Decrease of Protease-Resistant PrPSc Level in ScN2a Cells by Polyornithine and Polyhistidine

Title
Decrease of Protease-Resistant PrPSc Level in ScN2a Cells by Polyornithine and Polyhistidine
Author
이성은
Keywords
Prion; polyornithine; polyhistidine; cationic amino acid polymer
Issue Date
2018-10
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
Citation
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v. 28, No. 12, Page. 2141-2144
Abstract
Based on previous studies reporting anti-prion activity of poly-L-lysine and poly-L-arginine, cationic poly-L-ornithine (PLO) and poly-L-histidine (PLH), anionic poly-L-glutamic acid (PLE) and uncharged poly-L-threonine (PLT) were investigated in cultured cells chronically infected by prions to determine anti-prion efficacy. While PLE and PLT did not alter the level of PrPSc, PLO and PLH exhibited potent PrPSc inhibition in ScN2a cells. These results suggest that anti-prion activity of poly-basic amino acids is correlated with cationicity of their functional groups. Comparison of anti-prion activity of PLO and PLH proposes that anti-prion activity of poly-basic amino acids is associated with the acidic cellular compartments.
URI
http://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.1807.07045http://repository.hanyang.ac.kr/handle/20.500.11754/105737
ISSN
1017-7825
DOI
10.4014/jmb.1807.07045
Appears in Collections:
RESEARCH INSTITUTE[E](부설연구소) > INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY(약학기술연구소) > Articles
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