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Development of a novel celecoxib-loaded nanosuspension using a wet media milling process

Title
Development of a novel celecoxib-loaded nanosuspension using a wet media milling process
Author
최한곤
Issue Date
2018-09
Publisher
GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH
Citation
PHARMAZIE, v. 73, No. 9, Page. 498-502
Abstract
To develop a novel celecoxib (CXB)-loaded drug delivery system, numerous nanosuspensions were prepared with various polymers and surfactants using a wet media milling process, and their particle sizes were subsequently determined. A 24 full factorial design was used to identify the most appropriate preparation conditions. Pharmacokinetics of the selected nanosuspension were performed in rats and compared with those of a drug powder and a commercial CXB-loaded product. Among the carriers investigated, copovidone and sodium lauryl sulphate gave the smallest particle size of the drug in the nanosuspension. In particular, the nanosuspension prepared with 5% CXB, 4% copovidone, and 0.1% sodium lauryl sulphate, under the appropriate conditions, showed a particle size of approximately 190 nm, which was physically stable for at least 8 weeks. This nano-suspension provided a significantly higher plasma concentration and AUC in rats as compared with the drug powder and the commercial product. Thus, this novel CXB-loaded nanosuspension is a promising candidate with excellent stability and enhanced oral bioavailability. © 2018 Govi-Verlag Pharmazeutischer Verlag GmbH. All rights reserved.
URI
https://www.ingentaconnect.com/contentone/govi/pharmaz/2018/00000073/00000009/art00003http://repository.hanyang.ac.kr/handle/20.500.11754/105712
ISSN
0031-7144
DOI
10.1691/ph.2018.8035
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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