Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2019-05-22T07:42:19Z | - |
dc.date.available | 2019-05-22T07:42:19Z | - |
dc.date.issued | 2018-08 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 13, Page. 4627-4639 | en_US |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://www.dovepress.com/cyclic-rgd-conjugated-pluronicreg-blending-system-for-active-targeted--peer-reviewed-article-IJN | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/105663 | - |
dc.description.abstract | Background: Blending micellar systems of different types of polymers has been proposed as an efficient approach for tailor-made drug formulations. The lamellar structure of hydrophobic polymers may provide a high drug loading capacity, and hydrophilic polymers may provide good colloidal stability. Methods: In this study, the anticancer model drug docetaxel was loaded onto a nanosized blending micellar system with two pluronics (L121/F127). To achieve increased antitumor activity, the cyclic arginine-glycine-aspartic acid tripeptide (cRGD) as an active tumor targeting ligand was conjugated to the blending system. Results: The docetaxel-loaded Pluronic blending system exhibited a higher drug loading capacity than that of F127 and showed high colloidal stability with a spherical structure. cRGD conjugates demonstrated enhanced drug cellular uptake and anticancer activity against alpha v beta 3 integrin-overexpressing U87MG cancer cells. In vivo animal imaging also revealed that the prepared cRGD-conjugated nanoparticles effectively accumulated at the targeted tumor site through an active and passive targeting strategy. Conclusion: Accordingly, the prepared nanosized system shows potential as a tailor-made, active targeting, nanomedicinal platform for anticancer therapy. We believe that this novel nanoplatform will provide insights for advancement of tumor therapy. | en_US |
dc.description.sponsorship | This research was supported by a Chung-Ang University Graduate Research Scholarship in 2017 and supported by National Research Foundation of Korea (NRF) grants funded by the Korean government (MSIP) (NRF-2015R1A5A1008958). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | DOVE MEDICAL PRESS LTD | en_US |
dc.subject | blending micellar system | en_US |
dc.subject | docetaxel | en_US |
dc.subject | cyclic RGD | en_US |
dc.subject | Pluronic L121/F127 | en_US |
dc.subject | active targeting | en_US |
dc.subject | nanomedicine | en_US |
dc.title | Cyclic RGD-conjugated Pluronic® blending system for active, targeted drug delivery | en_US |
dc.type | Article | en_US |
dc.relation.volume | 13 | - |
dc.identifier.doi | 10.2147/IJN.S171794 | - |
dc.relation.page | 4627-4639 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.contributor.googleauthor | Lim, Chaemin | - |
dc.contributor.googleauthor | Moon, Junseong | - |
dc.contributor.googleauthor | Sim, Taehoon | - |
dc.contributor.googleauthor | Hoang, Ngoc Ha | - |
dc.contributor.googleauthor | Won, Woong Roeck | - |
dc.contributor.googleauthor | Lee, Eun Seong | - |
dc.contributor.googleauthor | Youn, Yu Seok | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.contributor.googleauthor | Oh, Kyungsoo | - |
dc.contributor.googleauthor | Oh, Kyung Taek | - |
dc.relation.code | 2018000855 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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