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Cyclic RGD-conjugated Pluronic® blending system for active, targeted drug delivery

Title
Cyclic RGD-conjugated Pluronic® blending system for active, targeted drug delivery
Author
최한곤
Keywords
blending micellar system; docetaxel; cyclic RGD; Pluronic L121/F127; active targeting; nanomedicine
Issue Date
2018-08
Publisher
DOVE MEDICAL PRESS LTD
Citation
INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 13, Page. 4627-4639
Abstract
Background: Blending micellar systems of different types of polymers has been proposed as an efficient approach for tailor-made drug formulations. The lamellar structure of hydrophobic polymers may provide a high drug loading capacity, and hydrophilic polymers may provide good colloidal stability. Methods: In this study, the anticancer model drug docetaxel was loaded onto a nanosized blending micellar system with two pluronics (L121/F127). To achieve increased antitumor activity, the cyclic arginine-glycine-aspartic acid tripeptide (cRGD) as an active tumor targeting ligand was conjugated to the blending system. Results: The docetaxel-loaded Pluronic blending system exhibited a higher drug loading capacity than that of F127 and showed high colloidal stability with a spherical structure. cRGD conjugates demonstrated enhanced drug cellular uptake and anticancer activity against alpha v beta 3 integrin-overexpressing U87MG cancer cells. In vivo animal imaging also revealed that the prepared cRGD-conjugated nanoparticles effectively accumulated at the targeted tumor site through an active and passive targeting strategy. Conclusion: Accordingly, the prepared nanosized system shows potential as a tailor-made, active targeting, nanomedicinal platform for anticancer therapy. We believe that this novel nanoplatform will provide insights for advancement of tumor therapy.
URI
https://www.dovepress.com/cyclic-rgd-conjugated-pluronicreg-blending-system-for-active-targeted--peer-reviewed-article-IJNhttp://repository.hanyang.ac.kr/handle/20.500.11754/105663
ISSN
1178-2013
DOI
10.2147/IJN.S171794
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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