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Role of Autophagy in Endothelial Damage and Blood-Brain Barrier Disruption in Ischemic Stroke

Title
Role of Autophagy in Endothelial Damage and Blood-Brain Barrier Disruption in Ischemic Stroke
Author
배옥남
Keywords
autophagy; blood-brain barrier; disease progression; endothelial cells; endothelial progenitor cells
Issue Date
2018-06
Publisher
American Heart Association
Citation
STROKE, v. 49, No. 6, Page. 1571-1579
Abstract
The global burden of neurological diseases including stroke has significantly increased, 1 and an urgent need exists to develop new treatment strategies. Impairment of autophagic regulation has been observed in diseases including neurodegenerative diseases and ischemic stroke, suggesting that modulation of autophagy could be a potential therapeutic target. 2 Endothelial cells (ECs) maintain homeostasis by regulating the vascular tone and permeability and endothelial dysfunction is associated with diverse cardiovascular diseases (CVDs). The integrity of the blood-brain barrier (BBB), which shows selective permeability for substances into the brain, is significantly impaired under ischemic stroke. This review focuses on autophagy in endothelial dysfunction in the context of ischemic stroke and potential targets for therapeutic manipulation.
URI
https://www.ahajournals.org/doi/abs/10.1161/strokeaha.117.017287http://repository.hanyang.ac.kr/handle/20.500.11754/105596
ISSN
0039-2499
DOI
10.1161/STROKEAHA.117.017287
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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