Copper(I)-Catalyzed Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Azidoformates and Aryl Terminal Alkynes

Title
Copper(I)-Catalyzed Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Azidoformates and Aryl Terminal Alkynes
Author
민선준
Keywords
ONE-POT SYNTHESIS; CLICK CHEMISTRY; ROOM-TEMPERATURE; SULFONYL AZIDES; ANTI-3-ARYL-2,3-DIBROMOPROPANOIC ACIDS; MEDICINAL CHEMISTRY; ORGANIC AZIDES; SODIUM-AZIDE; SOLID-PHASE; CYCLOADDITION
Issue Date
2018-04
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF ORGANIC CHEMISTRY, v. 83, No. 8, Page. 4805-4811
Abstract
The copper(I)-catalyzed azide-alkyne cycloaddition reaction has been extensively studied and widely applied in organic synthesis. However, the formation of 1,2,3-triazoles with electron-deficient azide has been a challenging problem. In this report, we have demonstrated the formation of regioselective 1,4-disubstituted 1,2,3-triazoles from various types of aryl terminal alkynes and azidoformates, which are electron-deficient azides, using a commercialized [Cu-(CH3CN)(4)]PF6 copper(I) catalyst under mild conditions.
URI
https://pubs.acs.org/doi/abs/10.1021/acs.joc.8b00022http://repository.hanyang.ac.kr/handle/20.500.11754/105470
ISSN
0022-3263
DOI
10.1021/acs.joc.8b00022
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > CHEMICAL AND MOLECULAR ENGINEERING(화학분자공학과) > Articles
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