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Artificial skin models for animal-free testing

Title
Artificial skin models for animal-free testing
Author
조용우
Keywords
Artificial skin models; Animal alternatives; Safety evaluation; Toxicity; Animal-free testing
Issue Date
2018-03
Publisher
Springer Netherlands
Citation
Journal of Pharmaceutical Investigation, v. 48, No. 2, Page. 215-223
Abstract
Since 2013, as ethics for animal experiments has been strengthened in the European Union, artificial skin models have attracted attention as an alternative to animal testing for assessing the safety and toxicity of products. Driven by regulatory authorities and industry demands, various artificial skin models have been developed by combining various biomaterials and human cells as well as using a variety of techniques, including freeze-drying, 3-D printing, electrospinning, and microfluidic system. Elaborately designed artificial skin models which closely mimic the human skin can be highly valuable and effective tools to replace in vivo animal tests for the evaluation of the safety and efficacy in the field of cosmetic and pharmaceutical industries as well as for the basic studies on cell to cell interactions, cell to extracellular matrix interactions, tissue formation and development. This review recapitulates diverse fabrication techniques for artificial skin models and their main applications.
URI
https://link.springer.com/article/10.1007/s40005-018-0389-1http://repository.hanyang.ac.kr/handle/20.500.11754/105420
ISSN
2093-5552
DOI
10.1007/s40005-018-0389-1
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MATERIALS SCIENCE AND CHEMICAL ENGINEERING(재료화학공학과) > Articles
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