Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김효준 | - |
dc.date.accessioned | 2019-05-22T01:49:14Z | - |
dc.date.available | 2019-05-22T01:49:14Z | - |
dc.date.issued | 2018-03 | - |
dc.identifier.citation | EXPERIMENTAL DERMATOLOGY, v. 27, No. 3, Page. 285-288 | en_US |
dc.identifier.issn | 0906-6705 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/full/10.1111/exd.13506 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/105416 | - |
dc.description.abstract | Skin cancer is the most common type of cancer. The incidence rate of skin cancer has continuously increased over the past decades. In an effort to discover novel anticancer agents, we identified a novel tubulin inhibitor STK899704, which is structurally distinct from other microtubule-binding agents such as colchicine, vinca alkaloids and taxanes. STK899704 inhibited microtubule polymerization leading to mitotic arrest and suppressed the proliferation of various cancer cell lines as well as multidrug resistance cancer cell lines. In this study, our investigation is further extended into animal model to evaluate the effect of STK899704 on skin carcinogenesis in vivo. Surprisingly, almost 80% of the tumors treated with STK899704 were regressed with a one-fifth reduction in tumor volume. Furthermore, the efficacy of STK899704 was nearly 2 times higher than that of 5-fluorouracil, a widely used skin cancer therapeutic. Overall, our results suggest that STK899704 is a promising anticancer chemotherapeutic that may replace existing therapies, particularly for skin cancer. | en_US |
dc.description.sponsorship | R&D Convergence Program, South Korea, Grant/Award Number: CAP-16-03-KRIBB; Basic Science Research Program, South Korea, Grant/Award Number: MRC (2017R1A5A2015541), and NRF-2016R1A2B3011389; Bio and Medical Technology Development Program, South Korea, Grant/Award Number: NRF-2014M3A9B5073938 | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | WILEY | en_US |
dc.subject | anticancer therapy | en_US |
dc.subject | mitotic inhibitor | en_US |
dc.subject | skin cancer | en_US |
dc.subject | STK899704 | en_US |
dc.subject | tubulin inhibitor | en_US |
dc.title | A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 27 | - |
dc.identifier.doi | 10.1111/exd.13506 | - |
dc.relation.page | 285-288 | - |
dc.relation.journal | EXPERIMENTAL DERMATOLOGY | - |
dc.contributor.googleauthor | Hwang, Joonsung | - |
dc.contributor.googleauthor | Soung, Nak Kyun | - |
dc.contributor.googleauthor | Han, Ho Jin | - |
dc.contributor.googleauthor | Lee, Yongjun | - |
dc.contributor.googleauthor | Choi, Tae Woong | - |
dc.contributor.googleauthor | Mun, Jiyun | - |
dc.contributor.googleauthor | Cha-Molstad, Hyunjoo | - |
dc.contributor.googleauthor | Lee, Kyung Ho | - |
dc.contributor.googleauthor | Kim, Hyo Joon | - |
dc.contributor.googleauthor | Lee, Hee Gu | - |
dc.contributor.googleauthor | Hong, Jin Tae | - |
dc.contributor.googleauthor | Ahn, Jong Seog | - |
dc.contributor.googleauthor | Kwon, Yong Tae | - |
dc.contributor.googleauthor | Kim, Bo Yeon | - |
dc.relation.code | 2018002075 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF MOLECULAR AND LIFE SCIENCE | - |
dc.identifier.pid | kimhj104 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.