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Therapeutic application of GPR119 ligands in metabolic disorders

Title
Therapeutic application of GPR119 ligands in metabolic disorders
Author
김영미
Keywords
GPR119; metabolic diseases; non-alcoholic fatty liver disease; physiological; pharmacological effects; synthetic ligands; type 2 diabetes mellitus
Issue Date
2018-02
Publisher
WILEY
Citation
DIABETES OBESITY & METABOLISM, v. 20, No. 2, Page. 257-269
Abstract
GPR119 belongs to the G protein-coupled receptor family and exhibits dual modes of action upon ligand-dependent activation: pancreatic secretion of insulin in a glucose-dependent manner and intestinal secretion of incretins. Hence, GPR119 has emerged as a promising target for treating type 2 diabetes mellitus without causing hypoglycaemia. However, despite continuous efforts by many major pharmaceutical companies, no synthetic GPR119 ligand has been approved as a new class of anti-diabetic agents thus far, nor has any passed beyond phase II clinical studies. Herein, we summarize recent advances in research concerning the physiological/pharmacological effects of GPR119 and its synthetic ligands on the regulation of energy metabolism, and we speculate on future applications of GPR119 ligands for the treatment of metabolic diseases, focusing on non-alcoholic fatty liver disease.
URI
https://onlinelibrary.wiley.com/doi/full/10.1111/dom.13062http://repository.hanyang.ac.kr/handle/20.500.11754/105375
ISSN
1462-8902
DOI
10.1111/dom.13062
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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