Repository at Hanyang UniversityCOLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학)CHEMICAL AND MOLECULAR ENGINEERING(화학분자공학과)Articles
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Construction of 8-Azabicyclo[3.2.1]octanes via Sequential DDQ-Mediated Oxidative Mannich Reactions of N-Aryl Pyrrolidines
- Title
- Construction of 8-Azabicyclo[3.2.1]octanes via Sequential DDQ-Mediated Oxidative Mannich Reactions of N-Aryl Pyrrolidines
- Author
- 민선준
- Keywords
- CATALYTIC ENANTIOSELECTIVE SYNTHESIS; DEHYDROGENATIVE COUPLING REACTIONS; BOND-FORMING REACTIONS; C-H FUNCTIONALIZATION; TROPANE ALKALOIDS; ASYMMETRIC-SYNTHESIS; TERTIARY-AMINES; AEROBIC CONDITIONS; DERIVATIVES; PHOTOREDOX
- Issue Date
- 2018-02
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANIC LETTERS, v. 20, No. 4, Page. 1175-1178
- Abstract
- A concise synthesis of 8-azabicyclo [3.2.1] octanes via sequential oxidative Mannich reactions is described. This approach involves an intermolecular oxidative Mannich coupling reaction between N-aryl pyrrolidines with TMS enol ether and a subsequent intramolecular oxidative Mannich cyclization of the corresponding silyl enol ether. DDQ is used as a key oxidant for both reactions.
- URI
- https://pubs.acs.org/doi/10.1021/acs.orglett.8b00098https://repository.hanyang.ac.kr/handle/20.500.11754/105362
- ISSN
- 1523-7060
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > CHEMICAL AND MOLECULAR ENGINEERING(화학분자공학과) > Articles
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