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Fabrication of terazocin-loaded poly(D,L-lactide) microspheres by an ultrasonic spray drying method and their release behaviors

Title
Fabrication of terazocin-loaded poly(D,L-lactide) microspheres by an ultrasonic spray drying method and their release behaviors
Author
조용우
Keywords
Utrasonic Spray Drying; Microspheres; Drug Delivery System; Terazocin; Poly(D,L-lactide)
Issue Date
2008-10
Publisher
AMER SCIENTIFIC PUBLISHERS
Citation
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v. 8, No. 10, Page. 5139-5142
Abstract
Terazocin should be frequently administered for a long period time for the treatment of benign prostatic hyperplasia which is one of the most common diseases in elderly men. Controlled delivery of terazocin using polymer microspheres has a great potential to solve the problem. In this study, terazocin-incorporated poly(D,L-lactide) (PDLLA) microspheres were fabricated by a novel ultrasonic spray drying (USD) method, which is a rapid one-step process. The approximate diameters of microspheres were in a range of between 0.3 and 3 mu m. SEM confirmed that the microspheres had a spherical shape and narrow size distribution. FT-IR spectroscopy demonstrated that the incorporated terazocin remained intact after the USD process. The microspheres showed a fast initial burst release of terazocin within nine hours, followed by a slow but steady release for 49 days, suggesting that these microspheres are highly promising for controlled drug delivery.
URI
https://www.ingentaconnect.com/content/asp/jnn/2008/00000008/00000010/art00047http://repository.hanyang.ac.kr/handle/20.500.11754/104994
ISSN
1533-4880
DOI
10.1166/jnn.2008.1138
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MATERIALS SCIENCE AND CHEMICAL ENGINEERING(재료화학공학과) > Articles
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