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Methylated Organic Metabolites of Arsenic and their Cardiovascular Toxicities

Title
Methylated Organic Metabolites of Arsenic and their Cardiovascular Toxicities
Author
배옥남
Keywords
Arsenic; Trivalent arsenic metabolite; Toxicity
Issue Date
2008-09
Publisher
한국독성학회
Citation
Toxicological Research, v. 24, No. 3, Page. 161-167
Abstract
Recently, arsenic-toxicity has become the major focus of strenuous assessment and dynamic research from the academy and regulatory agency. To elucidate the cause and the mechanism underlying the serious adverse health effects from chronic ingestion of arsenic-contaminated drinking water, numerous studies have been directed on the investigation of arsenic-toxicity using various in vitro as well as in vivo systems. Neverthless, some questions for arsenic effects remain unexplained, reflecting the contribution of unknown factors to the manifestation of arsenic-toxicity. Interestingly, very recent studies on arsenic metabolites have discovered that trivalent methylated arsenicals show stronger cytotoxic and genotoxic potentials than inorganic arsenic or pentavalent metabolites, arguing that these metabolites could play a key role in arsenic-associated disorders. In this review, recent progress and literatures are summarized on the metabolism of trivalent methylated metabolites and their toxicity on body systems including cardiovascular system in an effort to provide an insight into the future research on arsenic-associated disorders.
URI
http://koreascience.or.kr/article/JAKO200833337682968.pagehttp://repository.hanyang.ac.kr/handle/20.500.11754/104892
ISSN
1976-8257
DOI
10.5487/TR.2008.24.3.161
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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