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Preparation and in vivo evaluation of piroxicam-loaded gelatin microcapsule by spray drying technique

Title
Preparation and in vivo evaluation of piroxicam-loaded gelatin microcapsule by spray drying technique
Author
최한곤
Keywords
piroxicam; gelatin microcapsule; solubility; bioavailability
Issue Date
2008-08
Publisher
PHARMACEUTICAL SOC JAPAN
Citation
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v. 31, No. 6, Page. 1284-1287
Abstract
To develop a piroxicam-loaded gelatin microcapsule with enhanced bioavailability, a gelatin microcapsule encapsulated ethanol and piroxicam has been formulated by using gelatin as a water-soluble polymer shell. The aqueous solubility and bioavailability of piroxicam in piroxicam-loaded microcapsule in rats were then evaluated compared to piroxicam powder. The piroxicam-loaded gelatin microcapsule spherical in shape with smooth surface showed the geometric mean diameter of about 19 mu m. It had the piroxicam solubility of about 1.87 mg/ml and the amount of ethanol of about 4.37 mu g/mg. Furthermore, it gave significantly higher total plasma concentrations, C-max and area under the blood concentration-time curve (AUC) of piroxicam in rats than did piroxicam powder, indicating that the drug from gelatin microcapstile could be more orally absorbed in rats. In particular, the AUC of piroxicam in gelatin microcapsule was significantly about 2 fold increased compared to piroxicam powder. This enhanced oral relative bioavailability of piroxicam in gelatin microcapsule was contributed by the marked increase in the absorption rate of piroxicam due to the improved solubility of piroxicam. Thus, the piroxicam-loaded gelatin microcapsule developed using spray-drying technique with gelatin, sodium lauryl sulfate and ethanol would be useful to deliver piroxicam in a pattern that allows fast absorption in the initial phase, leading to better absorption.
URI
https://www.jstage.jst.go.jp/article/bpb/31/6/31_6_1284/_article/-char/ja/http://repository.hanyang.ac.kr/handle/20.500.11754/104801
ISSN
0918-6158
DOI
10.1248/bpb.31.1284
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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