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Salsolinol, an endogenous neurotoxin, enhances platelet aggregation and thrombus formation

Title
Salsolinol, an endogenous neurotoxin, enhances platelet aggregation and thrombus formation
Author
배옥남
Keywords
Platelets; salsolinol; Parkinson’s disease; alcoholism; thrombosis
Issue Date
2008-07
Publisher
SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN
Citation
THROMBOSIS AND HAEMOSTASIS, v. 100, No. 1, Page. 52-59
Abstract
Salsolinol, an endogenous neurotoxin, is known to be involved in the neuropathy of Parkinson’s disease and chronic alcoholism. In these diseases, increased thrombotic events are also commonly reported, yet the mechanism underlying remains poorly understood. Here we report that salsolinol can enhance agonist-induced platelet aggregation and granular secretion, which is essential in the thrombus formation. In rat and human platelets, agonist-induced platelet aggregation was significantly increased by salsolinol in a concentration-dependent manner. Agonist-induced granular secretions of serotonin and concomitant P-selectin expression were also augmented by salsolinol. α2-adrenergic blockers attenuated the salsolinol-enhanced aggregation and the inhibition of cyclic AMP generation was found, suggesting the involvement of α2-adrenergic receptor-mediated pathways in these events. In accord with the in-vitro results, in an arterial and venous thrombosis model in vivo in the rat, salsolinol shortened vessel occlusion time and increased thrombus formation, respectively. In conclusion, we demonstrated that sal-solinol can enhance agonist-induced aggregation and granular secretion in platelets through α2-adrenergic receptor activation, which resulted in the increased thrombus formation in vivo.These results suggest that salsolinol-enhanced platelet aggregation could be a possible contributing factor to the thrombotic events observed in Parkinson’s disease and alcoholism.
URI
https://www.thieme-connect.com/products/ejournals/html/10.1160/TH07-08-0529http://repository.hanyang.ac.kr/handle/20.500.11754/104756
ISSN
0340-6245
DOI
10.1160/TH07-08-0529
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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